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Allergies May All Be in the Gut, Study Finds

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Allergies May All Be in the Gut, Study Finds

Posted by Sapphire [422.74] on May 27, 2004 at 12:55:57:

Allergies May All Be in the Gut, Study Finds

Wed May 26, 5:05 PM ET Add Health - Reuters to My Yahoo!

WASHINGTON (Reuters) - Bugs in the gut may be causing many allergy symptoms felt in the head, from runny noses to trouble breathing, researchers said on Wednesday.

And antibiotics could be to blame, the researchers told a meeting of the American Society for Microbiology.

The findings could help explain the puzzling rise in asthma and allergies across the developed world in recent decades, the University of Michigan researchers said.

Antibiotics kill bacteria, but they can kill beneficial bacteria living in the intestines and colon. Many doctors recommend that patients taking antibiotics also eat "live" yogurt to replace some of these helpful microbes.

"We all have a unique microbial fingerprint-- a specific mix of bacteria and fungi living in our stomach and intestines," said Dr. Gary Huffnagle, an associate professor of internal medicine and of microbiology and immunology at the University of Michigan.

"Antibiotics knock out bacteria in the gut, allowing fungi to take over temporarily until the bacteria grow back after the antibiotics are stopped. Our research indicates that altering intestinal microflora this way can lead to changes in the entire immune system, which may produce symptoms elsewhere in the body."

Experiments on mice suggest that altering the balance of these so-called intestinal flora can affect the immune system.

"After antibiotics changed the mix of microbes in the gastrointestinal tract, the mice developed an allergic response in the lungs when exposed to common mold spores," Huffnagle said in a statement. "Mice that didn't receive the antibiotics were able to fight off the mold spores."

Huffnagle told the meeting that if the findings also hold true in people, they could help explain why asthma and allergies are on the rise.

"Anything you inhale, you also swallow," Huffnagle said in a statement.

"So the immune cells in your GI (gastrointestinal) tract are exposed directly to airborne allergens and particulates. This triggers a response from immune cells in the GI tract to generate regulatory T-cells, which then travel through the bloodstream searching the body for these antigens."

The immune system cells then block the development of allergic responses.

When antibiotics wipe out the bacterial population in the GI tract, yeast and fungi move in and multiply.

Fungi may secrete compounds called oxylipins, which can control the type and intensity of immune responses, Huffnagle told the meeting, being held in New Orleans.

Having too many oxylipins may prevent the development of the regulatory T-cells, in turn allowing for a hyperactive immune response against allergens such as pollen, he proposed.

http://story.news.yahoo.com/news?tmpl=story&cid=571&e=5&u=/nm/health_allergies_dc



Re: Allergies May All Be in the Gut, Study Finds

Posted by Steve [135.4] on May 27, 2004 at 13:49:21:

In Reply to: Allergies May All Be in the Gut, Study Finds posted by Sapphire [422.74] on May 27, 2004 at 12:55:57:

Good info..But you have to kill the bad bugs before trying to replace the good ones..Silver Fox!



Re: Allergies May All Be in the Gut, Study Finds

Posted by Sapphire [422.74] on May 27, 2004 at 14:27:43:

In Reply to: Re: Allergies May All Be in the Gut, Study Finds posted by Steve [135.4] on May 27, 2004 at 13:49:21:

Steve,

I'm not sure that's true... seems like one can always supplement with probiotics.... they can only help, not hurt, and they a supposed to help get rid of the bad bugs, too.

Sappphire



Re: Allergies May All Be in the Gut, Study Finds

Posted by Steve [135.4] on May 28, 2004 at 10:35:17:

In Reply to: Re: Allergies May All Be in the Gut, Study Finds posted by Sapphire [422.74] on May 27, 2004 at 14:27:43:

Check with SHAPE but I have read it's true..Silver Fox!

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Re: Allergies May All Be in the Gut, Study Finds

Posted by Syl [705.883] on June 02, 2004 at 11:35:25:

In Reply to: Allergies May All Be in the Gut, Study Finds posted by Sapphire [422.74] on May 27, 2004 at 12:55:57:

Good article, Sapphire. It goes hand-in-hand with adam's post of May 28. I took so many antibiotics as a child, which could explain why I have asthma today. This could also be my prime susceptibility factor to toenail fungus.

Thank you,
Sylvia

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Re: Allergies May All Be in the Gut, Study Finds SISITYS? Archive

Posted by Walt Stoll [9.8] on June 03, 2004 at 11:39:12:

In Reply to: Allergies May All Be in the Gut, Study Finds posted by Sapphire [422.74] on May 27, 2004 at 12:55:57:

Thanks, Sapphire.

Walt

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