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FYI: Alpha lipoic acid for allergy

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FYI: Alpha lipoic acid for allergy

Posted by R. [2151.2032] on July 20, 2005 at 11:40:03:

I've been researching alpha lipoic acid for some time and had an idea that it might be beneficial to people with allergies because it helps the liver. I just found the following piece of info at www.cognis.com/veris/ResearchAlerts/November_2004_Research_Alert.asp:

"Mouse Study Suggests that Alpha-Lipoic Acid May Be Beneficial in Asthma

BACKGROUND: Asthma is characterized by the inflammation and constriction of the bronchi, which interferes with breathing. People with asthma have higher than normal levels of free radicals. Epidemiologic data suggest that high intake of antioxidant-rich foods may reduce asthma symptoms.

RESEARCH: In a laboratory study, researchers exposed mice to egg albumin (through foods and in an aerosol spray) to prime them for allergic reactions. Some of the mice also received supplemental alpha-lipoic acid, an antioxidant that is used to treat diabetic nerve disease.

RESULTS: Mice receiving alpha-lipoic acid had significantly fewer symptoms compared with unsupplemented animals. They benefited from reduced airway hyperresponsiveness, fewer immune cells entering the bronchi, and less scarring of lung tissue. In addition, mice receiving alpha-lipoic acid had lower IgE antibody levels in response to the egg albumin, lower free radical levels, and lower activity of nuclear factor kappa-B, a protein that turns on inflammation-promoting genes.

IMPLICATIONS: The researchers concluded that alpha-lipoic acid “effectively suppresses allergic inflammation and airway hyperresponsiveness in a mouse model of asthma.” The study adds to a body of research showing that free radicals and antioxidants influence asthmatic reactions.

Cho YS, Lee J, Lee TH, et al. Alpha-lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. Journal of Allergy and Clinical Immunology, 2004;114:429-435.

For the original scientific abstract, visit:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15316528"

It was interesting for me because my mother told me recently that she's allergic to eggs and eating them triggers respiratory problems for her. Maybe ALA will help with this and other things. It would be good if some of you tried it too and reported results. Therapeutic doses (at least, for severe liver problems and cancer) are around 1200 -- 1500 mg per day. It can be bought relatively cheaply at http://www.swansonvitamins.com/ and http://www.puritan.com/, I believe.



Re: FYI: Alpha lipoic acid for allergy Archive in allergy.

Posted by Walt Stoll [93.1889] on July 21, 2005 at 08:06:49:

In Reply to: FYI: Alpha lipoic acid for allergy posted by R. [2151.2032] on July 20, 2005 at 11:40:03:

Thanks, R.

I think it was Cayce who first predicted that the liver had a lot to do with allergy.

Walt

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