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I would very much appreciate opinions on this post; I've just read info on a molecule (AT-1001) that inhibits a toxin (Zonulin or a derivative of Zonulin) involved in intestinal permeability (Leaky Gut Syndrome), celiac disease, diabetes type 1, rheumatoid arthritis and possibly other autoimmune diseases. My question is if a substance could be used to kill off the bad intestinal bacteria but preserve the good bacteria (or include a substance to preserve or restore the good bacteria such as yogurt) and Zonulin is inhibited by AT-1001 could this in theory possibly safely help the underlying autoimmune disease and the LGS? What happens to an autoimmune disease if bad intestinal bacteria is eliminated and good bacteria is maintained or restored with yogurt?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12404235
Thank you! Mike-S
In Reply to: LGS, Autoimmune Disease Questions posted by Mike-S [80.56] on March 24, 2005 at 20:57:33:
Hi, Mike.
New to me.
I would be interested in hearing more about it.
Walt
In Reply to: Re: LGS, Autoimmune Disease Questions posted by Walt Stoll [93.1889] on March 25, 2005 at 11:28:16:
Dr. Stoll: This is everything I have on this. Thank You!!! Mike-S
http://gut.bmjjournals.com/cgi/content/full/49/2/159
http://www.clinsci.org/cs/100/0379/cs1000379.htm
Google search done on:
zonulin diabetes
Further info can be found at:
http://health.groups.yahoo.com/group/diabetes_int/message/68546
Probably need to join the group to read it.
(Zonulin protein discovery - University of Maryland School of Medicine.)
(Proceedings of the National Academy of Sciences 2-22-2005; pnas link below; info is allegedly free after six months on
http://www.freemedicaljournals.com/
)
Zonulin regulates intestinal permeability; plays a role in the destruction of pancreatic islet cells (insulin producing cells); zonulin is inhibited with AT-1001. May play a part in diabetes (possibly only type 1? possibly LADA?), celiac disease, MS, RA, and autoimmune
diseases.
=====================
Second Google search done on:
AT-1001 zonulin inhibitor OR inhibit OR inhibition OR inhibited
http://wonderfulcharities-diabetesnews.blogspot.com/
http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=10641
Many links I tried no longer discussed this topic (replaced with another topic);
Ivanhoe info is restricted after some period of time - maybe a week.
=====================
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=1\
5710870&dopt=Abstract
http://www.pnas.org/cgi/content/abstract/102/8/2916
I don't know if the following will work correctly (clickable in the link directly above):
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Link&db=PubMed&dbFrom=PubMed&f\
rom_uid=15710870
In Reply to: Re: LGS, Autoimmune Disease Questions posted by Mike-S [80.56] on March 26, 2005 at 17:41:54:
Thanks, Mike.
Looks like it should help. It remains to be seen whether it will end up being a monkey wrench in these extremely complex "gears".
Time will tell. It IS encouraging that research is beginning to unravel at least a small part of this mechanism. Perhaps the day will come soon when the conventional medical system will have to admit the reality of LGS.
Walt
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