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vit-c and cancer

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vit-c and cancer

Posted by nadam [2511.2425] on January 17, 2008 at 03:41:04:

The url below contains an article by John Hopkins Hospital regarding the role of vit-c in fighting cancer.
The article was circulated yesterday and to a large extent confirms the previously suspected role of vit-c and other antioxidants.

http://www.johnshopkinshealthalerts.com/reports/healthy_living/1548-1.html?ET=johnshopkins:e4296:160573a:&st=email&st=email&s=RYH_080116_005

The entire article is as follows:

Healthy Living Special Report
How Vitamin C Stops The Big “C”

2007 JOHNS HOPKINS PRESS RELEASE

Nearly 30 years after Nobel laureate Linus Pauling famously and controversially suggested that vitamin C supplements can prevent cancer, a team of Johns Hopkins scientists have shown that in mice at least, vitamin C -- and potentially other antioxidants -- can indeed inhibit the growth of some cancer tumors, just not in the manner suggested by years of investigation.

The conventional wisdom of how antioxidants such as vitamin C help prevent cancer growth is that they grab up volatile oxygen free radical molecules and prevent the damage they are known to do to our delicate DNA. The Hopkins study, led by Chi Dang, M.D., Ph.D., professor of medicine and oncology and Johns Hopkins Family Professor in Oncology Research, unexpectedly found that vitamin C's actual role may be to destabilize a tumor’s ability to grow under oxygen-starved conditions. Their work is detailed in the journal Cancer Cell.

"The potential anticancer benefits of antioxidants have been the driving force for many clinical and preclinical studies,” says Dang. "By uncovering the mechanism behind antioxidants, we are now better suited to maximize their therapeutic use.”

"Once again, this work demonstrates the irreplaceable value of letting researchers follow their scientific noses wherever it leads them,” Dang adds.

The authors do caution that while vitamin C is still essential for good health, this study is preliminary and people should not rush out and buy bulk supplies of vitamin C and other antioxidants as a means of cancer prevention.

The Johns Hopkins investigators discovered the surprise antioxidant mechanism while looking at mice implanted with either human lymphoma (a blood cancer) or human liver cancer cells. Both of these cancers produce high levels of free radicals that can be suppressed by feeding the mice supplements of antioxidants, either vitamin C or N-acetylcysteine (NAC).

However, when the Hopkins team examined cancer cells from cancer-implanted mice not fed the antioxidants, they noticed the absence of any significant DNA damage. "Clearly, if DNA damage was not in play as a cause of the cancer, then whatever the antioxidants were doing to help was also not related to DNA damage,” says Ping Gao, Ph.D, lead author of the paper.

That conclusion led Gao and Dang to suspect that some other mechanism was involved, such as a protein known to be dependent on free radicals called HIF-1 (hypoxia-induced factor), which was discovered over a decade ago by Hopkins researcher and co-author Gregg Semenza, M.D., Ph.D., director of the Program in Vascular Cell Engineering. Indeed, they found that while this protein was abundant in untreated cancer cells taken from the mice, it disappeared in vitamin C-treated cells taken from similar animals.

"When a cell lacks oxygen, HIF-1 helps it compensate,” explains Dang. "HIF-1 helps an oxygen-starved cell convert sugar to energy without using oxygen and also initiates the construction of new blood vessels to bring in a fresh oxygen supply.”

Some rapidly growing tumors consume enough energy to easily suck out the available oxygen in their vicinity, making HIF-1 absolutely critical for their continued survival. But HIF-1 can only operate if it has a supply of free radicals. Antioxidants remove these free radicals and stop HIF-1, and the tumor, in its tracks.

The authors confirmed the importance of this "hypoxia protein” by creating cancer cells with a genetic variant of HIF-1 that did not require free radicals to be stable. In these cells, antioxidants no longer had any cancer-fighting power.



Re: vit-c and cancer

Posted by Steve [5592.4388] on January 17, 2008 at 07:51:16:

In Reply to: vit-c and cancer posted by nadam [2511.2425] on January 17, 2008 at 03:41:04:

Thanks for posting that. Cancer like just about all other diseases is a result of years of a compermised immune system. The 3ls will help prevent cancer and vit. C is part of the program.

Silver Fox!



Re: vit-c and cancer

Posted by Michele [3355.4192] on January 17, 2008 at 08:56:05:

In Reply to: Re: vit-c and cancer posted by Steve [5592.4388] on January 17, 2008 at 07:51:16:

I disagree; there are children who develop cancer and that is not
through years of compromised immune systems; and many very
healthy athletes and others can fall victim to it.

I think we all want to THINK that we know what "causes" it but in
truth, if we did, we'd be curing it - so far, there isn't a cure. No
amount of stress reduction will cure cancer nor will eating organic
foods nor mega nutrients.

Cancer, like a headache, has many root causes. What you state is just
one of many but not the only.



Re: vit-c and cancer But it is..

Posted by Steve [5592.4388] on January 17, 2008 at 11:48:47:

In Reply to: Re: vit-c and cancer posted by Michele [3355.4192] on January 17, 2008 at 08:56:05:

Diaagree all you want. Young children that get cancer have a weak immune system. Could be they were born that way or from a poor diet. Those with a healthy immune system will not develope cancer. Try reading The Fit for Life Solution, by Harvey Diamond, chapter 5. Healthy people don't get cancer.

Silver Fox!

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Re: vit-c and cancer -- Archive in cancer.

Posted by Walt Stoll [93.1903] on January 18, 2008 at 08:12:52:

In Reply to: Re: vit-c and cancer posted by Michele [3355.4192] on January 17, 2008 at 08:56:05:

Thanks, Michele.

As you said: "many factors". However some of those factors (genetics for example) we still have no way of fighting. We can, however, do something about our immune function and that is what the 3LS addresses.

Until we identify, and be able to do something about, the majority of the causes we will still continue to have this condition in the human experience. Should we wait like helpless lambs until that day??????

Walt



Re: vit-c and cancer -- Archive in cancer.

Posted by Steve [5592.4388] on January 18, 2008 at 11:16:32:

In Reply to: Re: vit-c and cancer -- Archive in cancer. posted by Walt Stoll [93.1903] on January 18, 2008 at 08:12:52:

Not me..

Silver Fox!

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