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Hello:
From the Mercola Newsletter: Red hot chili peppers may cure Type I diabetes.
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Scientists at a Toronto hospital may have discovered proof that the body's nervous system helps trigger diabetes.
This stunning discovery, which shocked even the researchers who made it, could eventually lead to a near-cure of diabetes. Type I diabetes in particulars long been thought to be incurable.
Diabetic mice were injected with injected with capsaicin, the active ingredient in chili peppers, which counteracted the effect of malfunctioning pain neurons in the pancreas. The mice became healthy practically overnight.
This goes against the previous conventional wisdom that Type 1 diabetes is caused solely by the body's immune system attacking the pancreas. Apparently, the nerves also secrete neuropeptides that are crucial to the proper functioning of the pancreas.
The nervous system could also play a role in other chronic inflammatory conditions, such as asthma and Crohn's disease. The researchers have not confirmed their findings in people, but expect results from human studies within a year. However, a treatment may still be years away.
Cell December 14, 2006; 127(6): 1123-1135
National Post December 15, 2006
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Dr. Mercola's Comment:
Nearly 75 million Americans have diabetes or pre-diabetes, and while only 5 percent have the Type I version, its supposed incurability makes it by far the more challenging form of the illness. So this new research is potentially great news for Type I diabetics. Type 2 diabetes, of course, is already virtually 100 percent curable with natural methods frequently described on my site.
This experimental work with capsaicin is an absolutely unexpected discovery that came out of nowhere (except that some Jamaican researchers saw similar results some six years ago).
Capsaicin is well-known as a food component with healing properties. While its most common use has been as a component in topical creams for joint pain, it can also be useful for preventing and treating cancer. And like ginkgo, capsaicin is a natural product so the likelihood of serious side effects is very small.
This is in stark contrast to the synthetic drug solutions that are developed for chronic illness.
I can provide you with insights that will help you sort through the fraud and deception of the drug companies. When you hear or read of some "break though" drug solution for a chronic illness, you can run, don't walk away from it, because the overwhelming likelihood is that it will cause more harm than benefit.
This understanding makes it MUCH easier to view the news.
Note that this is true for the beginning of the 21st century. My guess is that this will likely hold true for many more years to come, but science is always advancing and I am certain they will have some radical new developments that will cause a serious refactoring of this principle.
On Vital Votes, Mary from Cabool, Missouri worries that the discovery will lead nowhere:
"This is a very promising article, but do you really think the pharmaceutical companies will even act on it? Either that or the price of chili peppers will go out of reach for most people."
The drug companies are notorious for taking natural remedies and making altered, synthetic versions of them that aren't as good so they can patent them and price them out of reach.
However, the good news is that this may end up having nothing to do with the drug companies. Seems like once the protocol is worked out, it may be something the average lay person will be able to implement.
I am REALLY excited about this news as it could be life saving for millions of people and the likelihood of any serious complications is virtually non-existent.
In Reply to: Red Hot Chili Peppers May Cure May Cure Type I Diabetes posted by PhillyLady [5066.2761] on January 14, 2007 at 11:17:34:
I'll add it to the list of cures.)
In Reply to: Red Hot Chili Peppers May Cure May Cure Type I Diabetes posted by PhillyLady [5066.2761] on January 14, 2007 at 11:17:34:
Thanks, Philly.
Interesting!
Walt
In Reply to: Red Hot Chili Peppers May Cure May Cure Type I Diabetes posted by PhillyLady [5066.2761] on January 14, 2007 at 11:17:34:
I got this from using a link at Mercola. The actual article would cost $30. This abstract refers to "diabetes-prone NOD mice" and to "pre-diabetic NOD mice" This is about prevention, not cure. BTW, one important thing to note when reading articles on curing type 1 is the term 'new-onset' which is a term for 'the beta cells ain't dead yet'-it's the state most type 1's are in when they are diagnosed, and this is the population that has the best shot at a cure. These people develop a more complete type 1 usually a few months later when the beta cells completely stop functioning and have less chance at a cure, as it's harder to repair something completely not functioning than something that is faltering.
At any rate, cayenne could be helpful to people with insulin resistance, type 1 and 2 and pre-diabetes, in everyday management of diabetes, if it, in fact, reduces insulin resistance when used in a dietary setting. The experiment is about injecting into the pancreas.
Abstract:
Summary
In type 1 diabetes, T cell-mediated death of pancreatic â cells produces insulin deficiency. However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas remains unclear. We report that TRPV1+ pancreatic sensory neurons control islet inflammation and insulin resistance. Eliminating these neurons in diabetes-prone NOD mice prevents insulitis and diabetes, despite systemic persistence of pathogenic T cell pools. Insulin resistance and â cell stress of prediabetic NOD mice are prevented when TRPV1+ neurons are eliminated. TRPV1NOD, localized to the Idd4.1 diabetes-risk locus, is a hypofunctional mutant, mediating depressed neurogenic inflammation. Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks. Concordantly, insulin sensitivity is enhanced in trpv1−/− mice, whereas insulitis/diabetes-resistant NODxB6Idd4-congenic mice, carrying wild-type TRPV1, show restored TRPV1 function and insulin sensitivity. Our data uncover a fundamental role for insulin-responsive TRPV1+ sensory neurons in â cell function and diabetes pathoetiology.
In Reply to: Re: Red Hot Chili Peppers May Cure May Cure Type I Diabetes. Archive posted by Walt Stoll [93.1889] on January 14, 2007 at 15:55:35:
Summary
In type 1 diabetes, T cell-mediated death of pancreatic â cells produces insulin deficiency. However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas remains unclear. We report that TRPV1+ pancreatic sensory neurons control islet inflammation and insulin resistance. Eliminating these neurons in diabetes-prone NOD mice prevents insulitis and diabetes, despite systemic persistence of pathogenic T cell pools. Insulin resistance and â cell stress of prediabetic NOD mice are prevented when TRPV1+ neurons are eliminated. TRPV1NOD, localized to the Idd4.1 diabetes-risk locus, is a hypofunctional mutant, mediating depressed neurogenic inflammation. Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks. Concordantly, insulin sensitivity is enhanced in trpv1−/− mice, whereas insulitis/diabetes-resistant NODxB6Idd4-congenic mice, carrying wild-type TRPV1, show restored TRPV1 function and insulin sensitivity. Our data uncover a fundamental role for insulin-responsive TRPV1+ sensory neurons in â cell function and diabetes pathoetiology.
In Reply to: Re: Red Hot Chili Peppers May Cure May Cure Type I Diabetes posted by Vince F [4572.3254] on January 14, 2007 at 12:44:16:
Vince:
It's a wonder herb/plant. I bought a big bag of dried hot peppers in 1997 in an Indian shop downtown and they're still potent. The bag only cost $1.20.
In Reply to: Re: Red Hot Chili Peppers May Cure May Cure Type I Diabetes. Archive posted by Walt Stoll [93.1889] on January 14, 2007 at 15:55:35:
You're welcome, Doc.
In Reply to: here's the abstract or the original article posted by ANN [1003.516] on January 14, 2007 at 16:00:10:
ANN:
Dr. Mercola wrote: "....while only 5 percent have the Type I version, its supposed incurability makes it by far the more challenging form of the illness. So this new research is potentially great news for Type I diabetics."
I copied the title of the article exactly as written in the Mercola newsletter I received. The title stated "MAY CURE DIABETES". I don't think they're trying to say that it's a certain cure, but that the discovery is very promising. Hopefully, they will find a cure.
In Reply to: Re: Red Hot Chili Peppers May Cure May Cure Type I Diabetes posted by PhillyLady [5066.2761] on January 14, 2007 at 16:53:12:
They can cure lots of things, just have to figure how to use them.
I don't think they ever loose their potentcy, and they May get Stronger.)) I have a bunch of dried habanaros that I bought years ago, and have to handle them with care. I use a sissors to cut them into Bite Sized pieces, and have to wash the sissors after, or I could handle them and burn myself somewhere I touched myself, like my eyes.
In Reply to: Re: here's the abstract or the original article posted by PhillyLady [5066.2761] on January 14, 2007 at 17:00:37:
Mercola seems to have gotten his info from an article in the National Post (Canada) instead of from the original research.
There are several good avenues of research going on in search of a cure for type 1, including work with inositol, injectable calcium, and some genetic work. It probably has more than one cause, in different people, so might have more than one cure.
In Reply to: Re: here's the abstract or the original article posted by PhillyLady [5066.2761] on January 14, 2007 at 17:00:37:
Mercola seems to have gotten his info from an article in the National Post (Canada) instead of from the original research.
There are several good avenues of research going on in search of a cure for type 1, including work with inositol, injectable calcium, and some genetic work. It probably has more than one cause, in different people, so might have more than one cure.
In Reply to: Re: here's the abstract or the original article posted by PhillyLady [5066.2761] on January 14, 2007 at 17:00:37:
Mercola seems to have gotten his info from an article in the National Post (Canada) instead of from the original research.
There are several good avenues of research going on in search of a cure for type 1, including work with inositol, injectable calcium, and some genetic work. It probably has more than one cause, in different people, so might have more than one cure.
In Reply to: Re: here's the abstract or the original article posted by PhillyLady [5066.2761] on January 14, 2007 at 17:00:37:
Mercola seems to have gotten his info from an article in the National Post (Canada) instead of from the original research.
There are several good avenues of research going on in search of a cure for type 1, including work with inositol, injectable calcium, and some genetic work. It probably has more than one cause, in different people, so might have more than one cure.
In Reply to: please read the abstract posted by ANN [1003.516] on January 14, 2007 at 16:02:38:
Thanks, Ann.
Walt
In Reply to: here's the abstract or the original article posted by ANN [1003.516] on January 14, 2007 at 16:00:10:
ANN:
In the article below, they offer an explanation of "NOD mice". It appears that NOD mice are a special strain of mice known to be prone to Type I diabetes. So it would seem that the mice in the study (from Mercola's article) were not random mice but mice specifically chosen for their genetic predisposition to diabetes.
Although the article below doesn't talk about the chili pepper/diabetes connection, it offers an explanation of the term NOD mice. That's why I posted it.
More searches revealed that the term "NOD" is given to this special strain of "Non-Obese Diabetic" mice. I could not find any instance where NOD referred to "Newly Onset Diabetes". Perhaps it has two meanings?
And in this article, they also explain that "NOD" means "Non-Obese Diabetic": http://www.naturaldiabetesremedies.com/articles/tags/diabetes-news/
In Reply to: Diabetes: More On NOD Diabetic Mice. posted by PhillyLady [5066.2761] on January 15, 2007 at 08:09:58:
This abstract refers to "diabetes-prone NOD mice" and to "pre-diabetic NOD mice"
I wasn't particularly focused on the NOD, but on the adjectives preceding them. As far as I know, new onset doesn't use the abbreviation NO. Thanks for the explanation. 10% of type 2's are thin, making the 'non-obese' designation not specific to type 1. Would be interesting to read the actual research paper to find out how the mice were rendered diabetic (there are various methods, the usual being to remove the pancreas, which wouldn't be sensible for this experiment). Some people (including my kids' NP) think the only function of the pancreas is to produce insulin. Actually, that's just a small part of the pancreas's job, and that part is done in the beta cells of the isles of langerhans. Other functions of the pancreas have to do with RNA and DNA so studies will have to go on to examine the effect of injections on all the other parts and functions of the pancreas. I've come across the suggestion (in Calvin and Agatha Thrash, MDs' book on diabetes) that hot spices like ginger and cayenne can actually cause chromasomal damage, so this is a direction that will need exploration.
I'm currently reading the book The Virus and The Vaccine ( pub. 2004) about the Salk and Sabin polio vaccines and their contamination with carginogenic SV-40. Reading about all the lab stuff and what the gov't chose not to pursue when they realized there was a problem is scary. Real problems with the NIH-major problem for America as at least half of us have been exposed.
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