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Researchers report that four consecutive days of moderate exercise in mice after they were infected with influenza protects them from dying, compared with mice that didn't exercise. This protective effect was more evident in mice greater than 16 weeks of age, an age at which they are immunologically more mature. The takeaway message: exercise regularly because you never know when you'll be exposed!
From American Physiological Society
Jerry Mittelman, DDS, FAPM
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In Reply to: Immunological benefits of even short term exercise. Archive. posted by Walt Stoll [9.8] on October 09, 2004 at 06:11:54:
Thanks, Walt.
Personally, I've learnt to exercise every day and stick to it. There are so many benefits! Even if only jog for 10 minutes - the difference in how I feel is incredible.
They did not specify, but Ï guess they implied aerobic exercise?
In Reply to: Immunological benefits of even short term exercise. Archive. posted by Walt Stoll [9.8] on October 09, 2004 at 06:11:54:
Thanks Walt,
Sometimes when I feel tired, I make myself to go to the gym anyway and after the workout, when I leave the gym, I feel energized and ready for my chores. It's a big part of my life and always will be.
In Reply to: Immunological benefits of even short term exercise. Archive. posted by Walt Stoll [9.8] on October 09, 2004 at 06:11:54:
you post for us.. This one is great.. even a tad of exercise.. I have no elevator and climb 3 flights each
day.. somedays get a bit .. frustrated with pkges. but
know.. it is goodfor me.. just pace it.. that is all..
Have a lovely week-end..
Sedona :)
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by Sonja [298.1329] on October 09, 2004 at 08:25:19:
Thanks Sonja.
Sounds like it but they did not specify. Aerobic exercise has been the only kind that has been proven to have the most effects in humans and that has been known for more than 30 years. They just have never tested it like this before. Of course, considering how much faster mice live than humans the timing would also be longer in humans. Perhaps that is why it has not yet been tested this way in humans.
However, my personal experience (as well and that of any routine exerciser) says that this result is obvious--at least after 6 weeks.
Walt
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by WOW [1317.65] on October 09, 2004 at 11:14:44:
Thanks, WOW.
That is the very best way to do it. As one gets older and unable to continus such a vigorous program, graduating to long distance swimming or other aerobic underwater exercises is ideal. Finally, at the end of life, programs like Tai Chi can be acomplished even while sitting down.
This is covered thoroughly in Jan's and my new book coming out soon.
Walt
In Reply to: Immunological benefits of even short term exercise. Archive. posted by Walt Stoll [9.8] on October 09, 2004 at 06:11:54:
Walt,
Is it not funny how we keep learning over and over how good exercise is for the body and mind..
Silver Fox!
In Reply to: Immunological benefits of even short term exercise. Archive. posted by Walt Stoll [9.8] on October 10, 2004 at 06:04:14:
Thanks Walt,
After my prolonged fast it was a little hard to get started on exercise program again and the first time was very difficult, seemed like the muscles didn;t want to cooperate but yesterday, the second time was easier and I felt stronger. The main thing is to stick to the program.
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by WOW [1317.65] on October 10, 2004 at 11:20:30:
Thanks, WOW.
You got that right! In my opinion, it is not a good idea to stop exercising when fasting although cutting back on the intensity is not a bad idea.
Walt
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by Walt Stoll [9.8] on October 11, 2004 at 06:30:49:
Thanks Walt,
I was researching different opinions on exercise during fasting and they were very mixed. Some were saying not to engage in anything strenious, others were saying it's OK and yet others said to take a complete rest with no exercise at all (while fasting on water alone). I did take light walks but I consider them only a light activity since my workouts at the gym are usually very intense and I didn't want to use all my energy and waste my musle tissue on zero calories. Yesterday I was back to an hour of cardio at 75-80% of maximum capacity, at around 135-140 consistant pulse during the workout.
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by WOW [1317.65] on October 11, 2004 at 11:22:11:
Hi WOW,
My understanding of exercise during fasting is you want to keep the body fluids circulating -- so walking or light aerobics, and rebounding, would be very appropriate. The reason you want to keep fluids moving is otherwise by fasting, you release toxins from the tissues and --- you don't want those toxins to just sit there, you want them to move to your elimination system and out of the body!
Best wishes,
Jan
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by Happygal [2070.350] on October 11, 2004 at 12:01:35:
Thanks Jan!
Since I plan on fasting regularely, I will do just that, walk for about 1/2 hour a day to keep those "juices" flowing :-)
In Reply to: Immunological benefits of even short term exercise. Archive. posted by Walt Stoll [9.8] on October 09, 2004 at 06:11:54:
Hi,
I contacted Dr. Mittelman about this article, and he sent the whole thing. Here it is:
Contact: Mayer Resnick
American Physiological Society
301.634.7209
301.332.4402 (cell)
mresnick@the-aps.org
After Flu Exposure, Mild Exercise Protects Mature Mice From Dying, But Not From Developing Symptoms
Takeaway message: Exercise regularly to stay healthy
Austin, Texas (Oct. 6, 2004) - University of Illinois researchers report that four consecutive days of moderate exercise in mice after they were infected with influenza protects them from dying, compared with mice that
didn't exercise. This protective effect was more evident in mice greater than 16 weeks of age, an age at which they are immunologically more mature. The takeaway message: exercise regularly because you never know when you'll be exposed!
Jeffrey A. Woods, PhD., and graduate student Tom Lowder at the Physical Fitness Laboratory, Department of Kinesiology, University of Illinois, Urbana, said their lab has a long-time interest in exercise and its influence on the immune system. (See "Exercise delays allogeneic tumor
growth and reduces intratumoral inflammation and vascularization," by Mark R. Zielinski et al., Journal of Applied Physiology, June 2004, published by the American Physiological Society.)
"We had completed a lot of in vitro studies, but we wanted to study now how exercise affected animals against a real infectious challenge," Woods said. The question they addressed in their study, "Protective effect of exercise on mortality due to influenza in mice," was "can exercise protect against morbidity and mortality?" While exercise protected mice from mortality, it didn't seem to have any affect on gross measures of sickness behavior like food intake and cage activity.
Editors note: Woods and Lowder are reporting their findings at the American Physiological Society's 2004 Intersociety Meeting, "The Integrative Biology of Exercise," Oct. 6-9 in Austin. The meeting schedule can be found at (http://www.the-aps.org/meetings/aps/austin/tentative.pdf). The complete
program, including abstracts, for the entire meeting is available upon request to members of the media.
Arrangements for on-site interviews, or telephone interviews during the meeting can be arranged through APS Communications Officer Mayer Resnick (cell: 301.332.4402, mresnick@the-aps.org) or through Stacy Brooks, APS Communications Specialist, 301.634.7253. From Oct. 6 (2p.m.) - Oct. 9, the onsite phone number is 512.482.8000, room 602, or 512.681.2950.
Daily exercise until symptoms are present
Male mice 11-20 weeks old were infected with influenza virus and then randomly assigned to exercise (EX) or home cage control (HCC). The EX mice were exercised for 20 to 30 minutes for four days and multiple subjective and standard measurements were recorded.
"The animals did very moderate exercise while they were mounting an immune response," Woods noted. As soon as symptoms appeared, exercise was stopped, to mirror how most people react once they come down with flu-like symptoms.
The mice were naïve, that is, they previously hadn't been exercising on a regular basis.
Results both striking and surprising; human flu vaccine reaction study underway
20-week-old mice that had exercised had significantly (p=0.008) higher survival rates (18 of 22) versus HCC of the same age (10 of 22). However, 11- to 16-week-old mice didn't show a significantly higher survival rate.
When all EX mice (47) were compared with all HCC mice (48), EX had twice the survival rate, 59% vs. 29.4% (p=0.003). None of the variables (food/water intake, random activity or symptom severity) proved to be reliable at predicting mortality. However, severe lethargy was apparent one to two days prior to death. And while there was a "marked, age-dependent effect on mortality, there was no effect at all on morbidity, which was somewhat surprising," Woods said.
The Illinois researchers plan on doing followup studies with animals that had been exercising regularly, as well as studies that to try and uncover the overall protective effect and its mechanisms. Areas that they'll be studying include: lung histopathology, cytokine gene and protein expression in the lung, and possible development of flu-specific immune cells.
At the moment, the laboratory also has a large NIH-funded human clinical trial underway examining whether or not moderate exercise training can improve immunological vigor --including responses to influenza vaccine -- in older adults.
* * *
The meeting is cosponsored by APS, the American College of Sports Medicine and the Canadian Society for Exercise Physiology. Additional support through unrestricted educational grants came from: the National Aeronautics
and Space Administration (NASA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMSD), Gatorade Sports Sciences Institute, Pfizer Inc. and the U.S. Army Research Institute of Environmental
Medicine (USARIEM).
* * *
The American Physiological Society was founded in 1887 to foster basic and applied bioscience. The Bethesda, Maryland-based society has more than 10,000 members and publishes 14 peer-reviewed journals containing almost 4,000 articles annually.
APS provides a wide range of research, educational and career support and programming to further the contributions of physiology to understanding the mechanisms of diseased and healthy states. In May, APS received the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring (PAESMEM).
# # #
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by WOW [1317.65] on October 11, 2004 at 11:22:11:
Thanks, WOW.
Sounds about right to me. Light exercise during a fast helps free up some of the toxins that a fast is designed to eliminate.
Walt
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by Happygal [2070.350] on October 11, 2004 at 12:01:35:
Perfect, Happygal!
Walt
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by Happygal (Jan) [2062.350] on October 11, 2004 at 22:09:45:
Wow! Happygal.
Thanks.
Walt
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by WOW [1317.65] on October 11, 2004 at 15:06:36:
my step dad had a stroke.
and he will not move .. far from his room
he comes to the L/r.. with his cane
buthe wont open his window.. sorry but
the room Smells.. awful. no air flowing
I feel ill.. when in there. .and cant stay
in it a long time at all.
i have offered to go down stairs to sit with him
on the bench etc.. and last time I saw him his skin
looks gray.. I m not being critical here.. but do
think walking would help him.. My own Dad died of cancer
and he worked.. but he was a different person. as all of us are.. My Mom (looks wonderful) waits on my step dad hand and foot. too. and she is not well hereself..
anyway.. not to ramble.. I LOVE TO WALK .. and
it is free. it is good.. and you take
in a magnificent slice of life.. each day
Best to all..
sad to see people aging..
Sedona..
off to walk..
:)))))))))
In Reply to: To all: isnt walking wonderful.. can you imagine if we could not walk?? posted by Sedona [1884.81] on October 12, 2004 at 07:46:49:
Hi Sedona,
It is very sad, we need to move as long as we live. My father is 90 and he still does everything for himself, eveworkouts out with some dumbells. He always tells me he doesn't want to be a burden. I guess I got it from him, I can;t imagine life without exercise and nature walks. It's such a big part of my life. As long as we move, we keep young, no matter waht out physical age is. It makes us young and alive.
In Reply to: Re: Immunological benefits of even short term exercise. Archive. posted by Walt Stoll [9.8] on October 12, 2004 at 07:20:30:
Thanks Walt!
In Reply to: To all: isnt walking wonderful.. can you imagine if we could not walk?? posted by Sedona [1884.81] on October 12, 2004 at 07:46:49:
Thanks, Sedona.
"Aging is not for sissies."
Everyone should be thankful that they still CAN walk and should take advantage of it while they can. The day will likely come when they cannot do it and that day will accelerate the time till they will be an invalid.
Unless we are lucky enough to die in an accident we ALL will eventually become invalids. The only question is how long before death this will happen.
Walt
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