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Hi Dr. Stoll,
I was overdosed on antibiotics as a child and adult until about 35 years old. I have had symptoms of endometriosis since I started menstruating at 16yo. I was positively diagnosed 5 years ago through surgery. The worst of the anitbiotic abuse was when I was 2 to 12 and then again from 24 to 35. In between I was on birth control pills from 18 to 24.
I was wondering if you have ever read or heard of any studies of correlation between antibiotic over-use and endometriosis. I am thinking that an insidious yeast infection permeating the intestines, uterus, mucous membranes etc. for years could actually cause this disease. Could the fungal microbes actually carry little pieces of endometrium during sloughing and migragte outside the uterus? That seems a lot more logical than just saying menstrual backflow causes this. There's got to be some factor that makes it "stick" in other places besides the uterus or else all women would have this disease from menstrual backflow.
It makes sense that the same pathology that causes leaky gut could do the same thing to the inside of the uterus. I wonder if this has ever been considered or studied.
In Reply to: Antibiotics & Endometriosis posted by Lorna [935.1351] on April 04, 2005 at 14:49:55:
Not sure about antibiotics and endometriosis, but there is a clear connection between dioxin exposure and endometriosis. Dioxin exposure has become ubiquitous, I'm afraid, and it's only getting worse. Soon every woman will have endometriosis, it will be expected.
In Reply to: Antibiotics & Endometriosis posted by Lorna [935.1351] on April 04, 2005 at 14:49:55:
Me again - here's an article about this. How lucky for all of us humans that we all carry a huge body burden of toxins, with no way to get rid of it, no safe place to hide from these toxins!
Toxic Link to Endo
ENDOMETRIOSIS and the TOXIC LINK
Endometriosis is an endocrine and immune disease that affects an estimated 89 million women and girls around the world, regardless of ethnic or social origin. The incidence of allergies, asthma, and chemical sensitivities in women with endometriosis is higher than in the general population. Women with endometriosis are also at higher risk for autoimmune diseases and certain types of cancers.
The connection with chemical toxins
Dioxin is a toxic byproduct of industrial and consumer processes that involve chlorine or incineration of chlorine-containing substances, such as PVC (polyvinyl chloride, commonly known as “vinyl”) plastics. The main sources of dioxins are medical waste incineration, municipal waste incineration, chemical and plastic manufacturing, some pesticides, and pulp and paper bleaching. PVC disposable medical devices, such as IV bags and tubing, are a major concern because they become medical waste, which is often incinerated. Dioxins formed during incineration are released into the air and travel via air currents, contaminating fields and crops. Cattle and other livestock eat the crops and the dioxin enters their tissue. Humans then eat the contaminated animal products.
In the early 1990s, the Endometriosis Association found that 79% of a group of monkeys developed endometriosis after exposure to dioxin in their food during a research study over ten years earlier. The severity of endometriosis found in the monkeys was directly related to the amount of TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin – the most toxic dioxin) to which they had been exposed . Monkeys that were fed dioxin in amounts as small as five parts per trillion developed endometriosis. In addition, the dioxin-exposed monkeys showed immune abnormalities similar to those observed in women with endometriosis .
As explained in books including Our Stolen Future, Dying from Dioxin, and The Endometriosis Sourcebook, scientists have come to the realization that certain chemical compounds, such as dioxin, have profound immunological and reproductive impacts at exposures far below the level known to cause cancer. These chemicals are known as endocrine disruptors and can mimic hormones and interfere with many physiological processes . Scientists are still researching the mechanisms that are used, but they already know that these man-made chemicals persist in the body for years. PCBs (polychlorinated biphenyls) are a group of dioxin-like chemicals that were used in industry until they were banned in the 1970s. Some PCBs persist in the environment for more than one hundred years. According to Endometriosis Association research, certain PCBs appear to be linked with TCDD in endometriosis in the monkeys. The severity of endometriosis correlated with the blood levels of a particular PCB .
Based on animal studies and observation of wildlife, impaired fertility is a result of exposure to endocrine disruptors. Infertility affects approximately 40% of women with endometriosis. The Endometriosis Association’s research registry provides data showing that endometriosis is starting at a younger age and is more severe than in the past. Could this be the result of a rising “body burden” level of dioxins and other endocrine disruptors?
It is imperative that we stop dioxin exposure now. These toxins are affecting our health and are threatening the health of future generations. Let’s join together and take action now! For more information on what you can do, contact the Environmental Coordinator at support@EndometriosisAssn.org.
Rier,S.E. et al. (1993). “Endometriosis in Rhesus Monkeys (Macaca Mulatta) Following Chronic Exposure to 2,3,7,8,-tetrachlorodibenzo-p-dioxin.” Fundamental and Applied Toxicology, Vol.21, pp.433-441.
Rier, S.E. et al. (2000). “Increased Tumor Necrosis Factor-a Production by Peripheral Blood Leukocytes from TCDD-Exposed Rhesus Monkeys.” Toxicological Sciences, Vol. 60, pp. 327-337.
Colborn, Theo et al. (1997). Our Stolen Future. Penguin Books USA Inc.
Rier, S.E. et al. (2001). “Serum Levels of TCDD and Dioxin-like Chemicals in Rhesus Monkeys Chronically Exposed to Dioxin: Correlation of Increased Serum PCB Levels with Endometriosis.” Toxicological Sciences, Vol. 59, No. 1, pp. 147-159.
In Reply to: Antibiotics & Endometriosis posted by Lorna [935.1351] on April 04, 2005 at 14:49:55:
Hi, Lorna.
I know of no studies about this relationship but it makes sense since I DO know of the direct relationship between antibiotic usage and dysbiosis, a common cause of LGS and subsequently possible C-RS which IS directly related to endometriosis. Listen to Anon.
Hope this helps.
Walt
In Reply to: Re: Antibiotics & Endometriosis posted by Anon [2726.1513] on April 04, 2005 at 17:22:57:
Thanks Anon,
Thank you so much for your information and time to answer my post. I had read this article also. But, it still doesn't explain the physiology or the mechanism of "how" endometriosis develops. William Crook thinks it does have to do with yeast. I wonder if pieces of the endometrium are carried by fungal bodies and subsequently latched on in other places. Dioxin is an endocrine disruptor and mimics hormones, which in turn can cause dysbiosis like Walt says.
I also read another article where "MEN" had been diagnosed with endometrium growing on their intestines. They had a form of endometriosis! They also had dysbiosis. But, how can men have endometrium in their system?
In Reply to: Re: Antibiotics & Endometriosis posted by Walt Stoll [93.1889] on April 05, 2005 at 08:16:12:
Thanks Walt. I have been helped tremendously since wellness. I have 1/2 the symptoms I used to have....now only to move onto PWFD, steady skilled relaxation and exercise and really nab it the rest of the way. :)
In Reply to: Re: Antibiotics & Endometriosis posted by Lorna [935.1351] on April 05, 2005 at 14:49:37:
Thanks, Lorna.
Keep on keeping on!
Walt
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