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Calcium Channel Blockers - Dr Stoll and anyone

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Calcium Channel Blockers - Dr Stoll and anyone

Posted by sonia [5538.1399] on February 06, 2009 at 05:22:27:

I know CCBs are drugs used for hypertension. What exactly is their action?

Do they block or reduce absorption of calcium? If so why? Does too much calcium cause high bp?

Surely it is dangerous to upset the absorption of calcium?


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Re: Calcium Channel Blockers - Dr Stoll and anyone

Posted by Walt Stoll [93.4968] on February 06, 2009 at 06:14:05:

In Reply to: Calcium Channel Blockers - Dr Stoll and anyone posted by sonia [5538.1399] on February 06, 2009 at 05:22:27:

Sonia,

The best person to explain this to you is your pharmacist.

Let us know what you learn.

Walt

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Re: Calcium Channel Blockers - Dr Stoll and anyone

Posted by Charles [448.2996] on February 06, 2009 at 11:03:15:

In Reply to: Calcium Channel Blockers - Dr Stoll and anyone posted by sonia [5538.1399] on February 06, 2009 at 05:22:27:

Sonia you have the whole world right at your fingertips.


Calcium Channel Blockers
(CCBs)
Lowering Blood Pressure Exercise Tips Slideshow Medical Author: Omudhome Ogbru, Pharm.D.
Medical Editor: Jay Marks, M.D.

What are calcium channel blockers (CCBs) and how do they work?
For what conditions are calcium channel blockers used?
Are there any differences among calcium channel blockers?
What are the side effects of calcium channel blockers?
With which drugs do calcium channel blockers interact?
What CCBs are available?

What are calcium channel blockers and how do they work?
In order to pump blood, the heart needs oxygen. The harder the heart works, the more oxygen it requires. Angina (heart pain) occurs when the supply of oxygen to the heart is inadequate for the amount of work the heart must do. By dilating the arteries, CCBs reduce the pressure in the arteries. This makes it easier for the heart to pump blood, and, as a result, the heart needs less oxygen. By reducing the heart's need for oxygen, CCBs relieve or prevent angina. CCBs also are used for treating high blood pressure because of their blood pressure-lowering effects. CCBs also slow the rate at which the heart beats and are therefore used for treating certain types of abnormally rapid heart rhythms.


For what conditions are calcium channel blockers used?
CCBs are used for treating high blood pressure, angina, and abnormal heart rhythms (for example, atrial fibrillation, paroxysmal supraventricular tachycardia).

They also may be used after a heart attack, particularly among patients who cannot tolerate beta-blocking drugs, have atrial fibrillation, or require treatment for their angina.

Unlike beta blockers, CCBs have not been shown to reduce mortality or additional heart attacks after a heart attack.

CCBs are as effective as ACE inhibitors in reducing blood pressure, but they may not be as effective as ACE inhibitors in preventing the kidney failure caused by high blood pressure or diabetes.

They also are used for treating:

pulmonary hypertension,


Raynaud's syndrome,


cardiomyopathy, and


subarachnoid hemorrhage.
CCBs are also used in the prevention of migraine headaches.


Are there any differences among calcium channel blockers?
CCBs differ in their duration of action, the process by which they are eliminated from the body, and, most importantly, in their ability to affect heart rate and contraction. Some CCBs [for example, amlodipine (Norvasc)] have very little effect on heart rate and contraction so they are safer to use in individuals who have heart failure or bradycardia (a slow heart rate). Verapamil (Calan, Isoptin) and diltiazem (Cardizem) have the greatest effects on the heart and reduce the strength and rate of contraction. Therefore, they are used in reducing heart rate when the heart is beating too fast.


What are the side effects of calcium channel blockers?
The most common side effects of CCBs are constipation, nausea, headache, rash, edema (swelling of the legs with fluid), low blood pressure, drowsiness, and dizziness.


Liver dysfunction and over growth of gums may also occur. When diltiazem (Cardizem) or verapamil (Calan, Isoptin) are given to individuals with heart failure, symptoms of heart failure may worsen because these drugs reduce the ability of the heart to pump blood.


Like other blood pressure medications, CCBs are associated with sexual dysfunction.



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Re: Calcium Channel Blockers - Archive in hypertension.

Posted by Walt Stoll [93.4968] on February 07, 2009 at 07:04:03:

In Reply to: Re: Calcium Channel Blockers - Dr Stoll and anyone posted by Charles [448.2996] on February 06, 2009 at 11:03:15:

Thanks, Charles.

Walt

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Re: Calcium Channel Blockers - Archive in hypertension.

Posted by Charles [448.2996] on February 07, 2009 at 15:02:39:

In Reply to: Re: Calcium Channel Blockers - Archive in hypertension. posted by Walt Stoll [93.4968] on February 07, 2009 at 07:04:03:

Dr. Stoll

I don't know much about patent classification but the Field Of Search for CCBs is 514/356, nicotinic acid and I do believe that nicotinic acid comes from nicotine. If a person was to go and check the patents on 514/356 they would find that not all of these patents are classified in 514/356 Field of Search but 424/266 which is a raw drug, 500s are finished drugs but 400s are raw drugs. Now at one time 424/266 was NICOTINE but that subclass, 266, seems to have disappeared.

Quite a few years ago I filed a lawsuit against the AMA saying that they aren't being completely truthful to the American people about tobacco as I already knew tobacco could dissolve blood clots, I didn't say smoking in my lawsuit yet when the AMA attornies filed for dismissal THEY said there is no evidence that SMOKING may prevent heart attacks. I submitted many patents that showed medicine that was being made out of this chemical in tobacco. Since I said that I had NOT had any negative medical occurance the judge said I don't have any standing with the court and he also said it was the craziest thing he had ever heard yet all these patents were included when I filed my lawsuit.

Now if you go to the patent office and look up nicotinic acid, I think you will find different results than what you find when you look up 514/356.

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Re: Calcium Channel Blockers - Archive in hypertension.

Posted by Walt Stoll [93.4968] on February 08, 2009 at 08:24:39:

In Reply to: Re: Calcium Channel Blockers - Archive in hypertension. posted by Charles [448.2996] on February 07, 2009 at 15:02:39:

Thanks, Charles.

In my opinion, I have come to the conclusion that putting the AMA and honesty in the same sentence is an oxymoron.

Walt

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Re: Calcium Channel Blockers - Dr Stoll and anyone

Posted by sonia [5538.1399] on February 09, 2009 at 03:40:26:

In Reply to: Re: Calcium Channel Blockers - Dr Stoll and anyone posted by Charles [448.2996] on February 06, 2009 at 11:03:15:

Thanks very much Charles. When I did a google I didn't get any good articles like this one. I appreciate it.

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Re: Calcium Channel Blockers - Dr Stoll and anyone

Posted by PeterB [12888.1399] on February 11, 2009 at 23:12:16:

In Reply to: Calcium Channel Blockers - Dr Stoll and anyone posted by sonia [5538.1399] on February 06, 2009 at 05:22:27:

"Surely it is dangerous to upset the absorption of calcium?"

Exactly. EVERY drug, when there is sufficient analysis of metabolic effect, can be shown to alter nutrient uptake and/or function in the human body, AS THAT IS HOW DRUGS CHANGE THE MARKERS USED TO "MEASURE" YOUR ILLNESS. If a drug did not modify some aspect of an individual's normal metabolic process, it would not be a drug. The answer, of course, is restoration of proper ratios of nutrients through changes in diet or supplementation.

  • www.drheise.com

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