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pancreatic enzymes

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pancreatic enzymes

Posted by pancreatic pierre on October 11, 2001 at 02:11:02:

(I have read the archives, books, and board.) The pancreatic enzyme supplements (bromelain or pancreatin, 500mg/meal) seem to be having the greatest immediate beneficial effect on my leaky gut. I accidentally tested this by going without them for 5 days and feeling gradually more and more miserable (slushy stools, etc). When I resumed dosage, the problems went away in a few days. I wondered why these enzymes have such effect. (1) Why does my small intestine like the storebought enzymes better than the "homemade" enzymes generated by my own pancreas?

I could not find information as to exactly how normal enzymes work in the archives. At http://arbl.cvmbs.colostate.edu/ I found detailed info about digestion. It seems that "homemade" enzymes in their simplest forms, trypsinogen (T) and chymotrypsinogen (CT) bump into nodes in the gut lumen called enterokinase. This makes T enzymes active, and when an active T bumps into a CT, the CT becomes active too. They then bump into polypeptides, stick to them, and pull away, breaking the polypeptides into smaller pieces. It looks like these pieces can then be absorbed and turned into energy. When I take the supplement enzymes, the gut lumen seems to work well. I thought the gut lumen was the part that was failing to replace itself because of stored stress effect hogging all the blood. (2) Walt, when you said a blood-starved gut wall functions imperfectly, do you mean there aren't enough working enterokinase to go around? (3) When I add more enzymes, is it making more use of the few enterokinase that are working correctly? (4) Is it risky to take these enzymes for a long period of time? (5) I read that they can metabolize muscle tissue, is it possible they can damage my slow-healing gut wall, or do those extras just never go active because they can't find a free enterokinase? (6) If damage is possible, should I do more SR each day than the 20 min x 2/day I've been doing to hurry the gut-healing process?



Re: pancreatic enzymes

Posted by Helping You on October 11, 2001 at 10:31:31:

In Reply to: pancreatic enzymes posted by pancreatic pierre on October 11, 2001 at 02:11:02:

I think that your small intestine "likes" these store-bought enzymes because your pancreas may not be procuding enough enzymes on its own right now. Here's a piece of information that people don't readily know. The body needs amino acids from proteins in order to produce enzymes necessary for digestion. If your body is short on any one of those amino acids, those enzymes will not br made properly. I have a question for you. have you ever been a vegetarian or lowered your protein intake to less than 20% of your diet?



Re: pancreatic enzymes

Posted by pancreatic pierre on October 11, 2001 at 11:53:56:

In Reply to: Re: pancreatic enzymes posted by Helping You on October 11, 2001 at 10:31:31:

Never been a vegetarian. I generally eat meat w/ veggies 2/3 meals a day, including a fair amount of beans/peas. I've sort of been thinking I should eat less protein, but haven't acted on it. I know you recommended plenty of it in previous posts.



Re: pancreatic enzymes (Archive in LGS.)

Posted by Walt Stoll on October 12, 2001 at 10:02:31:

In Reply to: pancreatic enzymes posted by pancreatic pierre on October 11, 2001 at 02:11:02:

Hi, Pierre.

In order:
1. The science of pancreatic enzymes (actually ALL GI enzymes) is just now in it's infancy. As you become a student of this , you can help keep all of us up in this rapidly progressing field.
2. At least that. Enzyme production and response is but a part of all that is going on.
3. Probably but (See #1.)
4. I do not think so. However, giving the gut it's best chance to heal (Dealing with the LGS.) is what I think is most important. We are not yet (and may never be) as good as God (Mother Nature) in doing this right.
5. No. Remember that the gut wall was designed to coexist with all GI enzymes in perfect health.
6. Well, it IS true that more SR can help. However the biggest benefit (per minutes expended) is the 20 minutes twice a day of PROVEN effective SR.

Hope this helps.

Walt



more findings

Posted by pancreatic pierre on October 12, 2001 at 14:06:03:

In Reply to: Re: pancreatic enzymes (Archive in LGS.) posted by Walt Stoll on October 12, 2001 at 10:02:31:

Walt, I need your opinion on the reliability of this article. It explores a possible link between pancreatic enzyme supplementation and colonic strictures in children with cystic fibrosis. 13 of 14 patients recieving high doses ( >10000 lipase/kg ) of enzyme supplement exhibited fibrosing colonopathy. (1) Is this problem of concern to typical LGS sufferers? (2) What/where is the formula to convert milligrams of pancreatin or bromelain to IUs of lipase? I want to see how many IUs I am taking. I am interested in making research of this nature my life's work, but don't know where to begin. I am 27 and have a BS in information science. (3) Any suggestions?



Re: more findings

Posted by Walt Stoll on October 13, 2001 at 10:31:56:

In Reply to: more findings posted by pancreatic pierre on October 12, 2001 at 14:06:03:

HI, Pancreatic Pierre.

>10,000 lipase/kg ???

Milligrams or units or grams or micrograms, etc., of lipase? Per kilograms of person???

Walt



Re: more findings

Posted by pancreatic pierre on October 13, 2001 at 17:48:30:

In Reply to: Re: more findings posted by Walt Stoll on October 13, 2001 at 10:31:56:

I'm pretty sure the lipase is measured in I.U.s and that kg is the weight of the child in kilograms.



Re: more findings

Posted by Walt Stoll on October 14, 2001 at 08:12:55:

In Reply to: Re: more findings posted by pancreatic pierre on October 13, 2001 at 17:48:30:

Thanks, Pierre.

I would be ihnterested in hearing more about this. Since the body normally produces a lot more than this, I do not understand how this could happen.

I must admit, though, that I am not an expert in this field.

Walt

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Re: pancreatic enzymes

Posted by Leslie on October 15, 2001 at 14:20:19:

In Reply to: Re: pancreatic enzymes posted by pancreatic pierre on October 11, 2001 at 11:53:56:

Dr. Stoll,

What is your expertise, as when ever anyone asks you a question, you always send them to the archives, as you don't have an answer. Do you have a PHD?



Re: pancreatic enzymes

Posted by Joanie on October 15, 2001 at 14:47:53:

In Reply to: Re: pancreatic enzymes posted by Leslie on October 15, 2001 at 14:20:19:

Dr. Stoll is an MD. He refers people to the archives because their questions have been asked before, and the answers are there. It saves him from having to retype the answers over and over again. Hope this answers your questions.

Namaste`

Joanie

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Re: pancreatic enzymes

Posted by Raisa on October 15, 2001 at 14:49:54:

In Reply to: Re: pancreatic enzymes posted by Leslie on October 15, 2001 at 14:20:19:

Hi, Leslie - The reason for that is that so many of the questions asked have been asked and answered many times before. That is why there are archives. Have you visited the archives? There is lots of interesting information in them about almost anything you can think of to do with staying or getting well. Raisa

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Re: pancreatic enzymes

Posted by Walt Stoll on October 16, 2001 at 09:46:46:

In Reply to: Re: pancreatic enzymes posted by Leslie on October 15, 2001 at 14:20:19:

Leslie,

Where do you think the information in the archives came from??? Listen to Raisa and Joanie (Thanks, guys!)

Walt

Follow Ups:


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