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High AST Levels

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High AST Levels

Posted by
John on April 06, 2001 at 01:02:50:


Approximately nine months ago I had blood work done which revealed my AST levels to be over 400. From that point, another blood test was done apporximately a week later and the AST level went down by over 100. Liver function tests revealed that I did not have a form of hepatitis. Over the past couple of months, I have had liver function tests done periodically and they have dropped slightly each time (last time being by 10 points--to 210, 3 months after the last test). I am doing all of this through my regular doctor and fear that he does not have knowledge of this situation. He is simply waiting for the levels to retrn to normal, however I have read that a drop in AST levels does not mean anything is improving and could mean the opposite. All other liver function tests have been normal. Should I be seeing a liver specialist at this point and is it possible that the AST levels could be representative of a problem nonrelated to my liver? I have had a sharp pain on my lower left side periodically the last few days, though I realize that this probably holds no relation. Any information would be helpful.

Thanks.



pulled this off a site.....

Posted by LT on April 07, 2001 at 06:31:17:

In Reply to: High AST Levels posted by John on April 06, 2001 at 01:02:50:


AST (SGOT)

Increase of aspartate aminotransferase (AST, formerly called "SGOT") is seen in any condition involving
necrosis of hepatocytes, myocardial cells, or skeletal muscle cells. [See "Bilirubin, total," below] Decreased
serum AST is of no known clinical significance.

and from another site..

Serum glutamic oxaloacetic transaminase (SGOT): An enzyme that is
normally present in liver and heart cells. SGOT is released into blood when the
liver or heart is damaged. The blood SGOT levels are thus elevated with liver
damage (for example, from viral hepatitis) or with an insult to the heart (for
example, from a heart attack). Some medications can also raise SGOT levels.
SGOT is also called aspartate aminotransferase (AST).

and from this site -- if all other liver enzymes are normal, could it possibly be a heart problem?


SGPT and SGOT

SGPT, which stands for serum glutamic pyruvic transaminase, is an enzyme found in
many organs and tissues.

Its measurement is useful as an index of liver disease. When the liver is not working
properly, the SGPT level in the blood increases.

Another enzyme, SGOT - serum glutamic oxalacetic transaminase - is also present in
the liver but is found in large quantities in heart muscle as well.

Both SGOT and SGPT appear in a higher than normal concentration in the blood when
there is damage to cells that contain them; the cell walls become permeable and allow
the enzymes to escape into the bloodstream.

When the liver is injured, both the SGOT and the SGPT are elevated. Soon after a
heart attack, the SGOT from the heart is increased, but the SGPT remains normal.

If you've had chest pain that is not typical of heart trouble, and the electrocardiogram
does not give a definite reading, the doctor will measure the levels of both enzymes.

When the SGOT is elevated and the SGPT is normal, the trouble lies in the heart or
other muscle and not the liver.

In addition, newer, more sensitive enzyme determinations are now available and are
used specifically for coronary patients.

Follow Ups:


Re: High AST Levels (Conventional monopoly--sigh!)

Posted by Walt Stoll on April 08, 2001 at 08:02:08:

In Reply to: High AST Levels posted by John on April 06, 2001 at 01:02:50:

Hi, John.

Your liver "specialist" is at least 50 years behind today's knowledge. At the very least you need true liver "function" tests instead waiting for the liver cells to be actually dead for the SGOT ot be elevated. See the liver archives. Use the most recent advances in boosting liver enzymatic activity and THEN, let us know what happens.

Walt



Hey Dr. Stoll.....

Posted by LT on April 08, 2001 at 12:21:24:

In Reply to: Re: High AST Levels (Conventional monopoly--sigh!) posted by Walt Stoll on April 08, 2001 at 08:02:08:

While we're speaking of liver enzymes....

My dog's AST(SGPT) keep rising. When her ALK Phos was rising, I gave her a Milk Thistle/Dandelion detox and they came right down. Now these are rising, and only these. Is the liver the *only* thing these the AST is associated with? Is it common for these to to act so independently?



Re: Hey Dr. Stoll.... (Archive in liver.).

Posted by Walt Stoll on April 10, 2001 at 09:51:22:

In Reply to: Hey Dr. Stoll..... posted by LT on April 08, 2001 at 12:21:24:

Hi, L.T.

These enzymes are in nearly all tissues of the body--just more in liver. They are only released into the blood when the cell dies. This is another reason to not DO these kinds of archaic tests and do only tests that pinpoint the liver function. I am surprised that your vet is not up on this yet since they seem to be ahead of the conventional human docs in nearly everything.

Walt



he's not very interested in them...

Posted by LisaT on April 11, 2001 at 04:39:12:

In Reply to: Re: Hey Dr. Stoll.... (Archive in liver.). posted by Walt Stoll on April 10, 2001 at 09:51:22:

since they are in the "normal" range. He doesn't seem to worry about the fact that they've risen by 10pts each blood test. Well, duh, somethings going on...I swear I'm going to have a partial medical degree by the time I get her healthy ;-)



Re: he's not very interested in them...

Posted by Vince F on April 11, 2001 at 10:05:23:

In Reply to: he's not very interested in them... posted by LisaT on April 11, 2001 at 04:39:12:


folowing the trends of tests will tell you where things
are heading and if you have an idea it might be good to
treat it before it Does get out of the normal range which
may be too late. I had all the symptoms of Combined System
Disease which is a defficency of B-12 and folate but the Drs
didn't but it since my blood cell size was within the normal
range but geting larger with each test and I had to lay it
out for a Dr and still pressure him to do the test and then
he just said to take a multi vitamin because i was very
low and then went on vacation. If I would have found info
on the condition earlier I may have avoided all my pain and
suffering since there is a 3-12 mo window to treat the
condition and I didn't sort it out for 18 and then i had to
beg and threaten to get B-12 shots and THEN the dr thought
he deserved a bonus if i won a law suit....Though he
wouldn't testify for me saying he couldn't afford the time.
I Used to like the guy but not for med knowledge which i
found out he lacked but he Had a great personality. Now I
wouldn't go to him if i was dying since he would probably
make sure I did.

VF



This is EXACTLY my point...

Posted by LisaT on April 11, 2001 at 17:56:39:

In Reply to: Re: he's not very interested in them... posted by Vince F on April 11, 2001 at 10:05:23:

I want to stop something before it really gets started, which it looks like is already happening. One of her vets gave her an herb combo and we'll see if that helps. These other docs/vets just drive me nuts -- and you have even more to be pi**es off about. Aaargh. That's all, just aaargh.

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