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If you are not familiar with CLA, you'd recommend to learn about it. Here's a very a short quote from www.lef.org:
"It is interesting that while it is chemically related to linolenic acid, conjugated linoleic acid (CLA) appears to have opposite effects in certain important areas. For instance, linolenic acid stimulates fat formation (lipogenesis) in adipose tissue, while CLA inhibits fat formation; linolenic acid tends to promote tumor growth, while CLA is an excellent inhibitor of tumor growth; linolenic acid makes cholesterol more susceptible to oxidation, while CLA makes cholesterol more stable."
I think they meant linileic (Omega-6) in this comparison, but I am not sure. By the way, according to study reports I've read, CLA reduces body fat a LOT, even without changing diet or lifestyle. Click below for a good source of info on CLA. Ignore the fact that they sell stuff -- it's still a good source of info.
In Reply to: CLA (conjugated linoleic acid) posted by R. on May 30, 2001 at 18:10:17:
Has anyone tried this stuff? Any good experiences?
In Reply to: Re: CLA (conjugated linoleic acid) posted by beth on May 31, 2001 at 01:33:14:
In Reply to: I would trust controlled studies more than one or two people on any board. nmi posted by R. on May 31, 2001 at 02:21:10:
Sure, I agree. But they did specifically mention that it worked for some people and didn't work for others. I just wanted to see if I could get any anecdotal experience, which I think should be considered before downing any unknown substance.
In Reply to: Re: I would trust controlled studies more than one or two people on any board. nmi posted by beth on May 31, 2001 at 13:21:00:
I listen to what people say and then look up the item and
see if I can find info that sounds like it might help or
work for me.
when having knee pains a friend told me I should get
Celebrex. I looked it up and read some interesting things
but it didn't seem like what I wanted. I didn't just want
a pain killer if I had damage. The search led me to MSM
and That sounded like a Much better choice and not just for
my knees. When i read that it was supposed to flush lactic
acid out of the muscles that could crystalize in them that
Sounded like Exactly what was happening to me since
physical activities made my muscles ache for days. It took
different brands to help different things but my knees and
muscles don't hurt at all and i don't have to take the MSM
after a small amount or very often unless i Really strain
myself and I heard Celebrex might be pulled off the market.
There is usually a lot of info out there and if something
fits and makes sense then it is worth a try.
VF
In Reply to: Re: I would trust controlled studies more than one or two people on any board. nmi posted by beth on May 31, 2001 at 13:21:00:
Yeah, that was kind of a cold and unhelpful response.
The least R could have done was give you links to
some controlled studies! Then, the studies PLUS
anecdotal experience could be very helpful.
I'm sorry I don't have any info for you, but just wanted to
say that if I did, I would be happy to share it. R, you do
not get a brownie button for the day, do not pass go, do
not collect $200.00
Lauri
In Reply to: Re: I would trust controlled studies more than one or two people on any board. nmi posted by lauri on May 31, 2001 at 15:26:50:
I want that $200! Please, actually follow a link I provided in my original post, and if you keep your eyes open, you may see references to the studies. You can keep your brownie button, though. I just want the money. After you read my post, you are welcome to come back here and appologize.
In Reply to: CLA (conjugated linoleic acid) posted by R. on May 30, 2001 at 18:10:17:
R, this seems to implicate the linolenic acid in flax seed oil as potentially HARMFUL. I've heard something to this effect from a site referencing Dr. Richard Peat's research. I'll research the link you provided. Take care.
In Reply to: Re: I would trust controlled studies more than one or two people on any board. nmi posted by Vince F on May 31, 2001 at 15:20:38:
It just sounded too good to be true, so I bought some at Mother's today to check it out. I have low blood sugar and have about 20 pounds I want to lose. I afraid of losing muscle while I diet so this does sound really good.
But FYI, must of the studies were done on animals. So, as a full fledged human, I will be the guinea pig for the board. I plan to test my blood sugar and measure my body fat during this time. I'll report back in a few months (if the stuff doesn't bother my bladder, which is a distinct possibility)
In Reply to: Oh, no! posted by R. on May 31, 2001 at 17:56:27:
Sorry about that. I did not follow all the links and
jumped to conclusions. I guess I'll have to use my 'get
out of jail free' card this time. :-)
Lauri
In Reply to: you're right! I humbly apologise posted by lauri on June 01, 2001 at 11:05:37:
In Reply to: Well, I went and bought some anyway.... posted by beth on May 31, 2001 at 22:04:30:
Did you get a good brand? Not all products contain what the bottle says it does. The amount can also be different from one stated on the bottle.
Be sure to take enough.
In Reply to: Re: CLA (conjugated linoleic acid) posted by Peter B on May 31, 2001 at 21:41:05:
I have a suspicion they meant to compare CLA with linoleic (Omega-6) fatty acid as Omega-6's are implicated with tumor growth. Or maybe they typed it right... I don't know.
Correct name is Ray Peat, not Richard.
In Reply to: Re: Well, I went and bought some anyway.... posted by R. on June 01, 2001 at 15:39:46:
I bought some that contains the Tonalin brand, which appears to be pretty popular and a well known brand. I did some research before I went shopping. It contains 750 mgs of CLA per softgel. I am taking two a day, so that's 1.5 grams a day. I weigh 140 lbs. Do you think I should I take more?
It doesn't appear to have any side effects at this time.
In Reply to: Re: Well, I went and bought some anyway.... posted by beth on June 01, 2001 at 18:11:13:
Hi, Beth
Will CLA cause problems to the heart or digestive system? I need to lose a lot of weight, and have several different problems. Like to know more about this product.
In Reply to: Re: Well, I went and bought some anyway.... posted by B.B. on June 01, 2001 at 19:51:06:
nmi
In Reply to: Re: Well, I went and bought some anyway.... posted by beth on June 01, 2001 at 18:11:13:
I don't know, Beth. Your guess is as good as mine. I brought up those issue only to make sure you paid attention to them because some (probably many if not most) people don't. I would think following a protocol similar to those used for successful studies would be wise. Also pay attention to when to take CLA with relation to meals. Perhaps, you will find more info somewhere else with more details. And then share your findings and results.
I've given the info about CLA to my sister and her husband who need to lose some weight. If they choose to take it, I will share their experience.
In Reply to: There is a link in the first message in this thread that will give you all the info you need. nmi posted by beth on June 01, 2001 at 20:51:29:
Beth,
The link was that of the manufacturer or seller of this product. Of course, I'd expect them to promote a safe product, and do not hold much credence in their link. Ii'm not lab rat, I'm a person, and I did not see any studies with human beings. Thought you had more information than what I'd already read. Apparently not. Sorry I asked.
Even though I need to lose weight, I do believe I'll continue going to my PCP. (BTW, he's into alternative medicine as well)
In Reply to: Re: CLA (conjugated linoleic acid) posted by R. on June 01, 2001 at 15:45:08:
In Reply to: Re: There is a link in the first message in this thread that will give you all the info you need. nmi posted by B.B. on June 01, 2001 at 23:27:37:
Maybe this will help, B.B.
Here are some of studies of effects of CLA done on humans. I didn't include those done in vitro on human cells. Keep in mind that CLA is an fatty acid you already consume with food if you eat meat and milk products. It is known that some CLA can be produced endogenously
by humans and is present in human breast milk.
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Conjugated Linoleic Acid Reduces Body Fat Mass in Overweight and Obese Humans
Conjugated linoleic acid (CLA) has been shown to reduce body fat mass (BFM) in animals. To investigate the dose-response relationships of conjugated linoleic acid with regard to BFM in humans, a randomized, double-blind study including 60 overweight or obese volunteers (body mass index 25–35 kg/m2) was performed. The subjects were divided into five groups receiving placebo (9 g olive oil), 1.7, 3.4, 5.1 or 6.8 g conjugated linoleic acid per day for 12 wk, respectively. Dual-energy X-ray absorptiometry was used to measure body composition [measurements at wk 0 (baseline), 6 and 12]. Of the 60 subjects, 47 completed the study. Eight subjects withdrew from the study due to adverse events; however, no differences among treatment groups were found regarding adverse events. Repeated-measures analysis showed that a significantly higher reduction in BFM was found in the conjugated linoleic acid groups compared with the placebo group (P = 0.03). The reduction of body fat within the groups was significant for the 3.4 and 6.8 g CLA groups (P = 0.05 and P = 0.02, respectively). No significant differences among the groups were observed in lean body mass, body mass index, blood safety variables or blood lipids. The data suggest that conjugated linoleic acid may reduce BFM in humans and that no additional effect on BFM is achieved with doses > 3.4 g CLA/d.
Journal of Nutrition. 2000;130:2943-2948
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In July 1997, the results of the first human study on CLA were released by the Medstat Research Ltd. group of Lillesterom, Norway. This 3-month preliminary study involved 20 healthy volunteers. Half the group was given six 500-mg CLA capsules a day, and the other half received identical-looking placebo capsules. The subjects were asked not to alter their diet or lifestyle; 18 of the 20 subjects completed the study protocol. The results showed that the people in the CLA group experienced a 15 to 20% reduction of average body fat, compared with the placebo group. In the CLA group, the initial body fat percentage was 21.3% at the beginning of the study, and only 17% body fat after 3 months on CLA capsules. In contrast, the placebo group started with an average of 22% body fat, and 3 months later recorded an average of 22.4% body fat.
Source: www.lef.org/protocols/prtcl-083a.shtml
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"...a dietary fatty acid with anticancer effects in skin, mammary, colon and stomach, conjugated linoleic acid (CLA; reviewed in Belury and Vanden Heuvel 1997 ), is a potent PPAR activator..."
[R.]: PPAR ligands have anticancer effects in extrahepatic tissues.
Journal of Nutrition. 1999;129:575-580
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The following is slightly different topic.
New findings on CLA clarify the benefits of meat and dairy products.
Conjugated linoleic acid or CLA has demonstrated a multitude of benefits in animal studies, including fat reduction, increase in lean muscle mass, reduced risk of diabetes, reversal of arteriosclerosis, and a marked reduction in tumor growth.
Many people do not realize, however, that there are 16 different types of CLA, each with a slightly different molecular shape. New research reveals that each type of CLA has a different set of benefits. The type of CLA most abundant in meat and dairy products (referred to by chemists as "cis-9, trans-11, CLA") appears to be the champion cancer fighter. Compared with another common type of CLA (trans 10, cis 12, CLA) it was a third more effective in blocking the growth of human cancer cells. (78% versus 58% reduction)
But the type of CLA found in meat and dairy products does not appear to reduce fat or increase lean muscle mass in humans. (That property is linked with trans 10, cis 12, CLA)
It will be some time before researchers match each type of CLA with its particular benefits.
(Information gleaned from abstracts presented at the 91st American Oil Chemists Society April 25-28, 2000 annual meeting. Special supplement to Inform, vol 11, no 5, 2000)
If this is true, then one must ensure he/she gets the type that fits the purpose.
In Reply to: More detailed info -- studies of effects of CLA in humans posted by R. on June 02, 2001 at 04:19:10:
Hi, R
Thank you very much for providing this information. I appreciate your assistance.:-)
In Reply to: More detailed info -- studies of effects of CLA in humans posted by R. on June 02, 2001 at 04:19:10:
Thanks, R.
Walt
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