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Don't Take Bone-Killing Drugs.

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Don't Take Bone-Killing Drugs.

Posted by PhillyLady [5444.1536] on October 10, 2006 at 11:24:01:

Hello:

Some prescribed bone-building drugs are actually killing the bones in your body. Here is a good article that explains it. It's from the Mercola newsletter:
----------------------------------

Why Take an Osteoporosis Drug That Kills Your Bones?

Bisphosphonates, a class of drugs used to prevent broken and deteriorating bones in cancer and osteoporosis patients, have been linked to a serious side effect called osteonecrosis, in which areas of bone in the jaw die.

However, while small, but increasing, numbers of complaints seem to be popping up, along with rising numbers of lawsuits aimed at the drugs' makers, many unanswered questions remain.

One major question is just how many people are suffering from osteonecrosis of the jaw related to bisphosphonates. There are two varieties of the drugs, one taken intravenously by cancer patients (Zometa and Aredia), the other taken in lower-dose pill form by those with osteoporosis (Fosamax, Actonel and Boniva).

Incidence of osteonecrosis among cancer patients is estimated at between 1 percent and 10 percent, while incidence among osteoporosis patients is unknown.

Doctors and Dentists Puzzled

Patients want to know whether they should stop taking the drugs, and whether osteonecrosis is treatable, but doctors and dentists don't have the answers. There is virtually no firm data available, and studies to provide answers are just beginning.

Invasive dental procedures, such as tooth extractions, may spur osteonecrosis, so some dentists have stopped treating patients taking the drugs. As for treatments, the best solution seems to be antibiotic rinses, but many people with the condition have not gotten better.

All bisphosphonate drug labels must include the link to osteonecrosis of the jaw. However, the drugs remain in bones for years, so no one knows how long the risk of osteonecrosis remains, even if the drug is no longer being taken.

Spartanburg Herald-Journal June 2, 2006

New York Times June 2, 2006 (Registration Required)


------------------------------------------------------

Dr. Mercola's Comment:

I warned you about the dangers of this class of drugs eight years ago. Apparently the mega-drug companies are getting pretty concerned as patients flock to oral surgeons and dentists for answers to this awful side effect, and firm answers are close to nonexistent.

Merck is the manufacturer of Fosamax, and it may actually suffer more damages from the lawsuits being filed on Fosamax than it will on Vioxx. The Fosamax suits claim it is a dangerous product because it can cause osteonecrosis, a condition that causes your jaw bone to rot and decay.

Fosamax's existing labeling provides no adequate warning of the drug's side effects. Why? It's a member of the nitrogenous biophosphonate family of drugs used for chemotherapy that have been associated with osteonecrosis. By the way, the newer drug, Boniva, is in the same class of drugs as Fosamax, and isn't all that different.

With Vioxx, Merck can get away with a lot of hogwash and say many things can cause heart attacks, not just Vioxx. But, with Fosamax, osteonecrosis of the jawbone is not caused by smoking or eating French fries.

Oral surgeons and many dentists started noticing this link five years ago. Last month, the American Association of Endodontists issued a position statement recommending that dental surgeons should check whether patients are on Fosamax and if so to look for this condition. This has become so common that dentists are now referring to this condition as fossy jaw.

In addition to this rotting jaw bone problem, Fosamax has also been associated with serious eye problems.

Merck grosses $3 BILLION a year from this deceptive scam. Don't be fooled into believing that Fosamax, or any drug, is the solution to improving your bone density.






Re: Don't Take Bone-Killing Drugs.

Posted by Ron [1540.2852] on October 10, 2006 at 12:06:51:

In Reply to: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1536] on October 10, 2006 at 11:24:01:

Hi Philly,

Do you know of any double-blind studies where those with tooth extractions were NOT TREATED with bisphosphonates
for comparison of osteoporosis presence?




Re: Don't Take Bone-Killing Drugs.

Posted by lovebird [20.2740] on October 10, 2006 at 12:18:35:

In Reply to: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1536] on October 10, 2006 at 11:24:01:

thanks Philly

Follow Ups:


Re: Don't Take Bone-Killing Drugs.

Posted by PhillyLady [5444.1351] on October 10, 2006 at 12:34:02:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by Ron [1540.2852] on October 10, 2006 at 12:06:51:

Hi Ron:

I'll try and find out. This isn't the first article I've read regarding osteonecrosis of the jaw resulting from taking bone-building drugs.



Re: Don't Take Bone-Killing Drugs.

Posted by Ron [1540.2852] on October 10, 2006 at 13:53:25:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1351] on October 10, 2006 at 12:34:02:

Hi Philly,

What have you heard about osteonecrosis of the hip ball due to taking Prednisone?
That is not a bisphosphonate.

It would appear that those who have bone trauma are frequently being tested for bone density and sure enough, those who are taking bisphosphonates are having trouble... What about those who do nothing after the trauma to the bone?




Re: Don't Take Bone-Killing Drugs.

Posted by Nutmeg [86.74] on October 11, 2006 at 01:52:19:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by Ron [1540.2852] on October 10, 2006 at 13:53:25:

Hi Ron,

I was going to post about the prednisone/steroid thing in this thread. My brother, age 53, just had his entire right shoulder joint and upper arm bones almost down to his elbow replaced due to avascular necrosis. He suffered with extreme pain and dysfunction for many months before he had the surgery and has been unable to work. Over the last couple of years he received several high-dose steroid injections for back pain, mostly stemming from a fall at work a couple of years ago. Apparently he was never informed of the osteonecrosis risks from taking the injections, or was told it was only a remote possibility. He considers himself fortunate that the necrosis showed up in his shoulder and arm, rather than the hip, which is more typical. The orthopedic surgeon said it was the worst case he'd ever seen.

Nutmeg




Re: Don't Take Bone-Killing Drugs.

Posted by Nutmeg [86.74] on October 11, 2006 at 02:02:37:

In Reply to: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1536] on October 10, 2006 at 11:24:01:

Hi Philly,

Thanks for posting this. The word needs to get out!

Fortunately the oral surgeon I took my mom to (she needed the last of her teeth extracted about a year ago) knew about this. We had already discontinued her Fosamax, but the oral surgeon said we had to wait until 6 months had elapsed before she could have the surgery, a matter of about 2 months more. To his credit, the office called back at the end of that time and asked me to schedule her in.

A couple of years before I had taken Mom to the dentist who is now my ex-dentist. She had a loose tooth, and he wiggled it loose)r) and yanked it while she was taking the Fosamax. Thankfully she never had a problem with her jaw bone, but the oral surgeon was horrified that it had been done this way.

Thanks for the info,
Nutmeg



Re: Don't Take Bone-Killing Drugs. (Archive in osteoporosis.)

Posted by Walt Stoll [93.1889] on October 11, 2006 at 08:07:13:

In Reply to: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1536] on October 10, 2006 at 11:24:01:

Amen, Philly.

Walt



Re: Don't Take Bone-Killing Drugs. (Archive in osteoporosis.)

Posted by PhillyLady [5444.1351] on October 11, 2006 at 08:39:53:

In Reply to: Re: Don't Take Bone-Killing Drugs. (Archive in osteoporosis.) posted by Walt Stoll [93.1889] on October 11, 2006 at 08:07:13:

You're welcome, Doc.

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Re: Don't Take Bone-Killing Drugs.

Posted by PhillyLady [5444.1351] on October 11, 2006 at 08:42:57:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by Nutmeg [86.74] on October 11, 2006 at 02:02:37:

Hi Nutmeg:

This drug isn't the panacea it was thought to be. It's a good thing your mom's oral surgeon was aware of the problems. Just think how many are not.

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Re: Don't Take Bone-Killing Drugs.

Posted by PhillyLady [5444.1351] on October 11, 2006 at 08:49:39:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by Ron [1540.2852] on October 10, 2006 at 13:53:25:

Ron:

I don't know enough about Prednisone to respond on its efficacy. I took it for two weeks once due to inflammation and it did nothing that I could detect (nothing positive, nothing negative).

I would think that ONLY those with bone problems or trauma are taking the bisphosphonates. That's why the studies show that these people are experiencing problems. If the drug is harming them, then it's a useless and dangerous drug. If it's not harming people with healthy bones, then there is no reason for them to take it. Why risk future osteonecrosis?



old archive - excellent info...Re: Don't Take Bone-Killing Drugs.

Posted by ~CT [3862.2844] on October 11, 2006 at 09:21:26:

In Reply to: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1536] on October 10, 2006 at 11:24:01:

From the askwaltstollmd.com archives...keeper!



Re: old archive - excellent info...Re: Don't Take Bone-Killing Drugs.

Posted by PhillyLady [5444.1351] on October 11, 2006 at 09:28:20:

In Reply to: old archive - excellent info...Re: Don't Take Bone-Killing Drugs. posted by ~CT [3862.2844] on October 11, 2006 at 09:21:26:

Hi ~CT:

Thanks. I didn't think to check the archives before posting this.

I just came across that information while reading the Mercola newsletter which they regularly send me. It's worth repeating:-)



Re: old archive - excellent info...Re: Don't Take Bone-Killing Drugs.

Posted by ~CT [3862.2844] on October 11, 2006 at 10:24:01:

In Reply to: Re: old archive - excellent info...Re: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1351] on October 11, 2006 at 09:28:20:

Hi PL ~ Yes!

I have been trying to find info from years gone by about the chemo bone drug before it was named Fosomax.

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Re: Don't Take Bone-Killing Drugs.

Posted by ~CT [3862.2844] on October 11, 2006 at 10:34:41:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by Ron [1540.2852] on October 10, 2006 at 13:53:25:

Hey Ron ~ FYI on the definition you may be seeking.

Are you aware what role bisphosphonates have in the treatment of cancer? How about the history of use prior to discovering the "bone building" capabilities and subsequent prescriptions aimed at menopausal women?



Re: Don't Take Bone-Killing Drugs.

Posted by Ron [1540.2852] on October 11, 2006 at 21:02:25:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by ~CT [3862.2844] on October 11, 2006 at 10:34:41:

Hi Philly,

Thanks for that informative article.

Fat cells seem to have a big part in blocking blood flow.
That explains why alcohol and prednisone do not mix without consequences.

Follow Ups:


Re: Don't Take Bone-Killing Drugs.

Posted by Naya [4725.14] on October 11, 2006 at 22:42:31:

In Reply to: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1536] on October 10, 2006 at 11:24:01:

Thanks, Philly, so much, for posting this. I am continually fighting with my rheumatologist about all these drugs. I refuse to take them. She gives me the prescriptions and I don't fill them. Now she wants to give me a shot once a year. I'm not up for that either.

I also heard that these drugs for osteoporosis can also cause irregular bone growth and tumors elsewhere in the body. Sorry, I don't have a source, but I did read it in several places.

Now I'm more determined than ever not to take anything except hydroxyapetite.

Again, thanks for the very valuable info.
Naya

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Re: Don't Take Bone-Killing Drugs.

Posted by Ron [1540.2852] on October 11, 2006 at 23:32:01:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by PhillyLady [5444.1351] on October 11, 2006 at 08:49:39:

Hi Philly,

I would guess that only those who go to doctors and are diagnosed with low bone density are taking bisphosphonates.

Lack of medical insurance could be the dividing line.



Follow Ups:


Re: Don't Take Bone-Killing Drugs. (There are benefits)

Posted by Ron [1540.2852] on October 14, 2006 at 23:08:43:

In Reply to: Re: Don't Take Bone-Killing Drugs. posted by Nutmeg [86.74] on October 11, 2006 at 01:52:19:

Hi Nutmeg,

With an injury to bones like that, osteoporosis can set in, causing terrible pain. Not only is osteonecrosis
a concern, but also actual bone pain called Reflex Sympathetic Dystrophy.

Bone strengthening meds such as Pamidronate could have
helped stop the pain more than the steroid shots which delayed healing.

Follow Ups:


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