Polycystic Ovarian Syndrome Archives

Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS)

[ Polycystic Ovarian Syndrome Archive ]
[ Main Archives Page ] [ Glossary/Index ]
[ FAQ ] [ Recommended Books ] [ Bulletin Board ]
   Search this site!
 
        

Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS)

Posted by Lisa_chicago on March 11, 2001 at 16:52:44:

Dr. Stoll:

I truly apprciate this bulletin board. It is not only an effective research tool but it also gives everyone a place to air their concerns.

(As a side note, I was not able to make an appointment with Dr. Terry Chappell last week, so I am going to try again this week).

(as you read these following keep in mind that I am also writing this so that if other women with PCOS have questions, they will come across this an internet search... and of course I'd like my questions answered)

Now back to the topic at hand, women with PCOS tend to
have very low progesteone levels. I recently read that progesterone affects the conversion of T4 to T3. (This is not something that I have ever read in any textbook on endocrinology or onthe thyroid and I found it to be very enlightening if it's true)

Question #1: Is it true that progesterone affects the conversion of T4 to T3? The less progesterone the less the conversion of T4 to T3.

I also just read that stress can supress the production of sex hormones. Stress can be defined as illness, like reoccurring bronchitis or upper respiratory infections, reoccurring colds, or more serious illnesses such as cancer etc. It can also be defined as working too hard, not sleeping enough, not eating properly etc. (Dr. Stoll - this site)


Also I came across some information that said that if a women's estogen level is too low (DR. Schwarzbein's book) she will constantly crave sweets. And that the estadiol level of women with PCOS is generally low.

Question #2: Is it true if the estogen level is too low that the craving for sweets will be great until the estrogen level is brought to a proper level.?


Thus a PROBLEM in PCOS in weight control. It is almost impossible to lose and keep weight off unless one is eating less than 1000 calories a day.

So let's sumarize: Stress lowers the sex hormone levels, the craving for sweets begins and the thyroid does not function as efficiently. The woman starts to gain weight which initiates and endrocrine cascade of its own and the weight increases faster as time goes on.

Dr.'s that are currently reasearching PCOS say that we (PCOS women) need to take metformin to improve the insulin sensitivity and therefore initiate weight loss. This pill causes nausea, diahrrea etc., thus it is not something that most people would want to take... It can also lead to lactic acidosis in some people.

To summarize, I'm just going to end because I wanted this to be an information blurb for those with PCOS and who are considering taking Metformin. Perhaps this will make them consider skilled relaxation before the medication.

Thank-you in advance, any comments would be welcome!!!!!

Lisa_chicago



good questions....all I know....

Posted by LT on March 11, 2001 at 17:16:20:

In Reply to: Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS) posted by Lisa_chicago on March 11, 2001 at 16:52:44:

is that people on thyroid supplements usually have to take a much higher amount when they are taking birth control pills because of problems with some type of absorption.

Follow Ups:


Re: Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS) (Archive)

Posted by Walt Stoll on March 13, 2001 at 09:39:01:

In Reply to: Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS) posted by Lisa_chicago on March 11, 2001 at 16:52:44:

Thanks, Lisa.

You got me. I am no longer in active practice so I have not kept up with the recent developments in this area. The only reason I have anything to offer on this BB is that I started a generation ahead of conventional medicine's current conversion to "seeing the forest for the trees" that is needed for the health-care system of the 21st century.

Ask Terry. He appreciates intelligent questions like this. If he does not know the answer he will find it for you while, in the process, he educates himself.

Let us know what you learn.

Walt



Re: Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS)

Posted by Sally on March 13, 2001 at 15:11:58:

In Reply to: Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS) posted by Lisa_chicago on March 11, 2001 at 16:52:44:

Lisa, I take T4 for hypothyroidism. I don't know if this will relate to your condition but there is quite a lot of information about the conversion from T4 to T3 and you might find something helpful for your condition. You can put "Mary Shomon" in your websearch. I also linked up with Dr. Lowe, who seems to have researched the subject at length. You could take a look since I was staying within my own area of interest, there could be a lot I missed.



Thanks Sally, www.thyroid.about.com is a great site!!! EOM

Posted by Lisa_chicago on March 14, 2001 at 13:54:03:

In Reply to: Re: Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS) posted by Sally on March 13, 2001 at 15:11:58:

Thanks Sally!!!!!!!

Follow Ups:


I found some info... The Textbook is Clinical Gynecological Endocrinology and Infertility... (PCOS, Polycystic Ovarian Syndrome, Stein Leventhal)

Posted by Lisa_chicago on March 19, 2001 at 14:58:02:

In Reply to: Re: Is it true that progesterone affects the conversion of T4 to T3? (Polycystic Ovarian Syndrome, PCOS) (Archive) posted by Walt Stoll on March 13, 2001 at 09:39:01:

Dr. Stoll,

As a side note, I have come across a book by Soeroff, Glass and I believe, Case called "Clinical Gynecological Endocrinology and Infertility". The Chapter that discusses the thyroid and reproduction covers the conversion of T4 to T3. It does not in particular discuss progesterones affect on the conversion but something I found to be VERY illuminationg was that the carbohydrate level affect the level of T3 found in the body.
The signifigance of this statement is, quite often women with PCOS can lose weight if they low carb. Now I'm not talking about eating no carbs or the Atkins diet, but I am saying when they cut out all forms of refined carbs, all sugar and sometimes they even have to eliminate grains before they can lose wight AND keep it off.
I wonder if these women (those with PCOS) had their T3 levels measured on a regular basis , if it would be found that their T3 levels are consistently low... I know that mine has been consistently low (lower than the lowest reference range) for greater than 10 years and I have PCOS.

Just some food for thought (no pun intended!!!)

Lisa_chicago

Follow Ups:


[ Polycystic Ovarian Syndrome Archive ]
[ Main Archives Page ] [ Glossary/Index ]
[ FAQ ] [ Recommended Books ] [ Bulletin Board ]
   Search this site!