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Mega-doses of Vitamin C harmful?

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Mega-doses of Vitamin C harmful?

Posted by Sapphire [2999.4205] on September 29, 2008 at 22:58:28:

Dr. Stoll, what are your thoughts on this?


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Re: Mega-doses of Vitamin C harmful? ooops!

Posted by Sapphire [2999.4205] on September 29, 2008 at 23:01:28:

In Reply to: Mega-doses of Vitamin C harmful? posted by Sapphire [2999.4205] on September 29, 2008 at 22:58:28:

Ooops, I had only read the studies on the bottom, but not the comment at the top re these only being 6 week studies... and are campaigns to discredit vitamin C...

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Re: Mega-doses of Vitamin C harmful? ooops!

Posted by Walt Stoll [93.4968] on September 30, 2008 at 08:35:11:

In Reply to: Re: Mega-doses of Vitamin C harmful? ooops! posted by Sapphire [2999.4205] on September 29, 2008 at 23:01:28:

Sapphire,

"Nuff said?" Let it suffice to say that I, personally, take 4 grams of esterified vitamin C twice a day and at least double that dose at the first sign of an impending viral infection. I have done this for at least 20 years.

Walt

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Re: Mega-doses of Vitamin C harmful?

Posted by Steve [5592.3394] on September 30, 2008 at 08:41:57:

In Reply to: Mega-doses of Vitamin C harmful? posted by Sapphire [2999.4205] on September 29, 2008 at 22:58:28:

Harmful? I know too much vitamin C makes me sick. Walt can handle a lot, I can't.

Silver Fox!

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Re: Mega-doses of Vitamin C harmful? ooops!

Posted by Barbara, Larry, and cats [15.4406] on September 30, 2008 at 12:39:06:

In Reply to: Re: Mega-doses of Vitamin C harmful? ooops! posted by Sapphire [2999.4205] on September 29, 2008 at 23:01:28:

Hi Sapphire,

Glad you had brought that up.

With my tooth & gums bump thing,
I started taking a lot of Vit. C
and was wondering if there was any
downside because I can see lots of
improvements in other areas besides
tooth and gums.

I will double check my amounts & match
with yours, Walts, & Silver Fox I think
it was. Good question.

Barbara, Larry, and Cats


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Re: Mega-doses of Vitamin C harmful?

Posted by Sapphire [2999.4205] on September 30, 2008 at 15:14:27:

In Reply to: Re: Mega-doses of Vitamin C harmful? posted by Steve [5592.3394] on September 30, 2008 at 08:41:57:

What happens, Steve, does it hurt your stomach and/or intestines?

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what brand?

Posted by mike [353.4501] on September 30, 2008 at 15:49:14:

In Reply to: Re: Mega-doses of Vitamin C harmful? ooops! posted by Walt Stoll [93.4968] on September 30, 2008 at 08:35:11:

Walt what brand of ester c do you take?


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Re: what brand?

Posted by Walt Stoll [93.4968] on October 01, 2008 at 07:15:54:

In Reply to: what brand? posted by mike [353.4501] on September 30, 2008 at 15:49:14:

Hi, Mike.

Early on (30 years ago) I think the brand mattered. Now, however, since the technoogy has matured, I do not think the brand matters. I get mine from Sam's or at Walmart.

Hope this helps.

Walt


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Re: Mega-doses of Vitamin C harmful? ooops!

Posted by Fork in the Road [358.4515] on October 01, 2008 at 10:55:28:

In Reply to: Re: Mega-doses of Vitamin C harmful? ooops! posted by Sapphire [2999.4205] on September 29, 2008 at 23:01:28:

Any bets on how long it will take the mainstream media to broadcast the negative report?

Fork

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Re: Mega-doses of Vitamin C harmful? ooops!

Posted by Sapphire [2999.4205] on October 01, 2008 at 16:38:04:

In Reply to: Re: Mega-doses of Vitamin C harmful? ooops! posted by Fork in the Road [358.4515] on October 01, 2008 at 10:55:28:

They'll be right on it!

Already my accupuncturist is warning not to take too much vitamin C saying it causes oxidation...

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Re: what brand?

Posted by mike [353.4501] on October 01, 2008 at 17:26:36:

In Reply to: Re: what brand? posted by Walt Stoll [93.4968] on October 01, 2008 at 07:15:54:

do you just get any brand that says Ester-C on it? thanks Doc
Mike

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Re: what brand?

Posted by Walt Stoll [93.4968] on October 01, 2008 at 17:34:28:

In Reply to: Re: what brand? posted by mike [353.4501] on October 01, 2008 at 17:26:36:

Yup.

Walt

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Re: what brand?

Posted by Eric d'cleric [1815.4686] on October 02, 2008 at 15:52:17:

In Reply to: Re: what brand? posted by Walt Stoll [93.4968] on October 01, 2008 at 17:34:28:

There is only one brand of Ester-C, and that is Ester-C. The courts
recently decided in favor of them and so other manufacturer's can no
longer make their version of it. So you only have the one choice now,
if you want "Ester-C." There are other products like Ascorbyl
Palminate, an oil soluble form, but that is all.

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Re: what brand? -- Archive in vitamin C.

Posted by Walt Stoll [93.4968] on October 03, 2008 at 07:55:38:

In Reply to: Re: what brand? posted by Eric d'cleric [1815.4686] on October 02, 2008 at 15:52:17:

Thanks, Eric!

Cogent explanation.

Walt

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Re: what brand?--Eric...

Posted by Nutmeg [4785.2450] on October 03, 2008 at 15:59:15:

In Reply to: Re: what brand? posted by Eric d'cleric [1815.4686] on October 02, 2008 at 15:52:17:

Are you finding this to be the case in your area now...only one brand of Ester-C available?

I was at my local health food store today and glanced at the vitamin C shelves. There were at least half a dozen brands of Ester-C for sale, none of which were Ester-C brand. I don't even think I've seen that brand anywhere. The other day I was in the supplement store and saw several of the regular brands of Ester-C there, as well.

What I have noticed is that last year and this year there seem to be one or two new formulations of what is supposed to be highly absorbable vitamin C. Last year it was Reacta-C and today I saw a different new one. Maybe these companies are getting new formulas out to replace the Ester-C.

Just curious,
Nutmeg



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Re: Mega-doses of Vitamin C harmful?

Posted by Steve [5592.3394] on October 03, 2008 at 16:11:59:

In Reply to: Re: Mega-doses of Vitamin C harmful? posted by Sapphire [2999.4205] on September 30, 2008 at 15:14:27:

Yes, I gat sick to my stomach.

Silver Fox!

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Re: what brand?--Eric...

Posted by craig [8177.4304] on October 05, 2008 at 22:48:17:

In Reply to: Re: what brand?--Eric... posted by Nutmeg [4785.2450] on October 03, 2008 at 15:59:15:

Like they said , Ester C is a trade name and manufactured by one Company.Used to be ZILA Pharma but believe they sold rights away.
Ubiquinol is another example. This enhanced CO Q 10 is available from several sources but all of it comes froma Japanese outfit , Kaneka.
When buying these products buy by price comparisons !

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Re: Mega-doses of Vitamin C harmful? FULL TEXT

Posted by Sapphire [2999.4205] on October 07, 2008 at 21:30:11:

In Reply to: Mega-doses of Vitamin C harmful? posted by Sapphire [2999.4205] on September 29, 2008 at 22:58:28:

Walt, Since this thread is being archived, here's the full text of the original article in case the link becomes disabled... ;-) Sapphire


~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Vitamin C Reported to Be Harmful in Large Amounts
When can a six week study that determines from questionable laboratory experiments that Vitamin C may play a role in serious disease make headlines?
When the study conclusions have no basis in logic, that's when!

It is important to understand that this conclusion was pure speculation by Jane E Brody of the New York Times. According to scientists Brody didn't interview, e.g. Bruce Ames of University of Califonia, the DNA damage, if any, is quickly repaired by B-vitamin based enzymes, and most food, such as onions and alpha sprouts, have been shown by these same experiments to cause "DNA Damage".

This is simply more evidence of the ongoing campaign, disguised as news, to discredit vitamin C. There is no experimental proof or evidence of any connection between vitamin C intake and the diseases warned about in these news articles. In fact, direct evidence to the contrary exists that vitamin C prevents these diseases.

The Latest Vitamin C Foundation Response to this Nonsense will be posted at this URL
Following Contributed by
Richard M. Humphrey


Yahoo! News Local Headlines
_________________________________________________________________

Thursday April 9 11:30 AM EDT

Too much Vitamin C can hazard health

NEW YORK, April 9 (UPI) _ Nobel laureate Linus Pauling used to tout
the benefits of massive doses of Vitamin C, but a British study says
taking more than 500 milligrams of the vitamin can be hazardous to the
genes.

Pauling, a chemist, used to take 12,000 milligrams a day.

But a report by chemical pathologists at the University of Leicester
in the current issue of Nature says instead of the antioxidant
benefits many expect from taking the vitamin supplement, they get the
opposite effect.

In a six-week study of 30 healthy men, the researchers found the
vitamin allowed free radicals to attack the adenine bases of DNA,
converting them to unhealthy levels of oxoadenine.

The research backs up laboratory studies done by Dr. Victor Herbert of
New York's Mount Sinai School of Medicine.

Herbert told the New York Times that vitamin C taken as supplements
converts harmless ferric iron to harmful ferrous iron, which attacks
the heart and other organs. Naturally occurring vitamin C has no such
harmful effect, he says.

The recommended daily intake of Vitamin C in the United States and
Britain is 60 milligrams a day, which can be obtained in foods, such
as six ounces of orange juice.

_-

Copyright 1998 by United Press International.

All rights reserved.



Reuters New Media

Yahoo! News Health Headlines
_________________________________________________________________

Wednesday April 8 6:34 PM EDT

High Doses Of Vitamin C May Be Harmful

LONDON (Reuters) -- The benefits of taking high doses of vitamin C as
a daily dietary supplement are questionable, and the practice may even
be harmful, according to a team of British researchers.

Dr. Ian D. Podmore and colleagues from the University of Leicester,
UK, report that vitamin C may have a deleterious effect when taken in
daily doses of 500 milligrams (mg). Their findings follow a trial of
30 healthy volunteers who were given doses of 500 mg -- or about eight
times the UK recommended daily allowance -- for a period of 6 weeks.

In the April 9th issue of the journal Nature, the researchers report
that at a dose of 500 mg/day vitamin C has both a damaging pro-oxidant
as well as a beneficial antioxidant effect on two important markers of
molecular damage, 8-oxoguanine and 8-oxoadenine.

"This is the first time that anybody has ever looked at doses or at a
supplementation dose in vivo, in human subjects, where we've managed
to measure genetic damage using the markers as indicated, 8-oxoguanine
and 8-oxoadenine," co-researcher Dr. Joseph Lunec told Reuters in an
interview.

Lunec said that at 500 mg/day vitamin C has the potential of reducing
oxidative stress in humans, but superimposed upon this is the
pro-oxidant, deleterious effect.

"The bottom line is that the dose (500 mg) is not necessarily the
optimal dose to use as a supplement," he said.

In their paper, the researchers note that the body's antioxidant
defences resist oxygen radicals that have the potential of damaging
DNA. However, if the balance of defences is altered, this can result
in oxidative stress. This stress can give rise to biomolecular damage
that may play a role in diseases such as cancer.

"Because we know DNA damage is a sequeli of oxidative stress and these
are supposedly antioxidants, then theoretically vitamin C should
reduce the oxidative stress," Lunec said.

"But in fact we've shown that although it does have a capacity at 500
mg to reduce that oxidative stress in humans, there is a deleterious
effect superimposed upon that," he added.

Lunec said that the value of taking high doses of vitamin C
supplements has been questioned in the past because it has been shown
that "...as soon as you saturate your tissues you begin to excrete the
vitamin C." The current study suggests that high doses may be doing
damage as well.

"We shouldn't tell people to take as much vitamin C as they can to
supplement their food," he said. SOURCE: Nature (1998;392:559)



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Re: Mega-doses of Vitamin C harmful? FULL TEXT

Posted by Walt Stoll [93.4968] on October 08, 2008 at 06:45:23:

In Reply to: Re: Mega-doses of Vitamin C harmful? FULL TEXT posted by Sapphire [2999.4205] on October 07, 2008 at 21:30:11:

Thanks, Sapphire.

Walt

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